Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 2/20 | 0.50 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.43 |
| ▸ | CHRNB4 | P30926 | 1/20 | 0.43 |
| ▸ | CHRNA3 | P32297 | 1/20 | 0.43 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.43 |
| ▸ | LTB4R2 | Q9NPC1 | 1/20 | 0.43 |
| ▸ | ACHE | P22303 | 1/20 | 0.43 |
| ▸ | BDKRB1 | P46663 | 6/20 | 0.41 |
| ▸ | SLC6A3 | Q01959 | 3/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | BRS3 | P32247 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | NAMPT | P43490 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9032066 | 0.84 | GAA (0.48) | CHRNB2CHRNB4CHRNA3CHRNA4LTB4R2 | |
| SCHEMBL9030773 | 0.83 | CHRNB2 (0.45) | CHRNB2CHRNB4CHRNA3CHRNA4LTB4R2 | |
| SCHEMBL8875151 | 0.79 | ACHE (0.48) | LTB4R2ACHESLC6A3SLC6A4BRS3 | |
| SCHEMBL18475231 | 0.78 | ACHE (0.42) | CHRNB2CHRNB4CHRNA3CHRNA4LTB4R2 | |
| SCHEMBL841128 | 0.77 | PDCD1 (0.53) | IDO1CHRNB2CHRNB4CHRNA3CHRNA4 | |
| SCHEMBL22349266 | 0.77 | LTB4R2 (0.43) | CHRNB2CHRNB4CHRNA3CHRNA4LTB4R2 | |
| SCHEMBL8958229 | 0.77 | ACHE (0.51) | CHRNB2CHRNB4CHRNA3CHRNA4LTB4R2 | |
| SCHEMBL7896979 | 0.77 | HDAC1 (0.47) | CHRNB2CHRNB4CHRNA3CHRNA4LTB4R2 | |
| SCHEMBL489306 | 0.76 | NR1H2 (0.48) | LTB4R2ACHESLC6A3SLC6A4BRS3 | |
| SCHEMBL283 | 0.76 | SLC6A3 (0.48) | LTB4R2ACHEBDKRB1SLC6A3SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0412594-B1 | Substituted triazolinones, triazolinethiones, and triazolinimines as angiotensin II antagonists | MERCK & CO INC (US) | 1996-01-03 | — | — | EP | disclosed |
| US-5411980-A | Substituted triazolinones, triazolinethiones, and triazolinimines as angiotensin II antagonists | MERCK & CO., INC. (US) | 1995-05-02 | — | — | US | disclosed |
| US-5336778-A | Substituted triazoles as angiotensin II antagonists | MERCK & CO., INC. (US) | 1994-08-09 | — | — | US | disclosed |
| EP-0586513-A1 | ACIDIC ARALKYL TRIAZOLE DERIVATIVES ACTIVE AS ANGIOTENSIN II ANTAGONISTS | MERCK & CO. INC. (US) | 1994-03-16 | — | — | EP | disclosed |
| US-5281614-A | Hypotensive agents, glaucoma or angiotensin antagonists | MERCK & CO., INC. (US) | 1994-01-25 | — | — | US | disclosed |
| WO-1992020662-A1 | ACIDIC ARALKYL TRIAZOLE DERIVATIVES ACTIVE AS ANGIOTENSIN II ANTAGONISTS | MERCK & CO., INC. (US) | 1992-11-26 | — | — | WO | disclosed |
| EP-0412594-A2 | Substituted triazolinones, triazolinethiones, and triazolinimines as angiotensin II antagonists | MERCK & CO. INC. (US) | 1991-02-13 | — | — | EP | disclosed |
| EP-0409332-A2 | Substituted triazoles as angiotensin II antagonists | MERCK & CO. INC. (US) | 1991-01-23 | — | — | EP | disclosed |