SCHEMBL8958836

SCHEMBL8958836

C[SiH](C)O[C@]1(n2cnc3c(NC(=O)c4ccccc4)ncnc32)C[C@@](O)(C(C)(C)C)[C@@H](CO)O1

nearest known ligand 0.41

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
PRMT6 Q96LA8 1/20 0.34
ADORA1 P30542 5/20 0.34
ADORA3 P0DMS8 3/20 0.33
ADORA2A P29274 2/20 0.33
ADORA2B P29275 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8937135 0.78 ADORA1 (0.34) PRMT6ADORA1ADORA3ADORA2AADORA2B
SCHEMBL1068384 0.78 PRMT6 (0.34) PRMT6ADORA1ADORA3ADORA2AADORA2B
SCHEMBL6402247 0.72 ADORA1 (0.39) ADORA1ADORA3ADORA2AADORA2B
SCHEMBL28165438 0.71 ADORA1 (0.45) ADORA1ADORA3ADORA2AADORA2B
SCHEMBL7153576 0.71 PRMT6 (0.32) PRMT6ADORA1ADORA3ADORA2AADORA2B
SCHEMBL24500565 0.71 PRMT6 (0.37) PRMT6ADORA1ADORA3ADORA2AADORA2B
SCHEMBL20225031 0.70 ADORA1 (0.37) PRMT6ADORA1ADORA3ADORA2AADORA2B
SCHEMBL17548588 0.70 ADORA3 (0.46) PRMT6ADORA1ADORA3ADORA2AADORA2B
SCHEMBL18949853 0.70 ADORA3 (0.46) PRMT6ADORA1ADORA3ADORA2AADORA2B
SCHEMBL17549849 0.70 ADORA3 (0.46) PRMT6ADORA1ADORA3ADORA2AADORA2B

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0691979-A1 NOVEL 5'-SUBSTITUTED NUCLEOSIDES AND OLIGOMERS PRODUCED THEREFROM SANOFI (FR) 1996-01-17 EP disclosed
WO-1994022890-A1 NOVEL 5'-SUBSTITUTED NUCLEOSIDES AND OLIGOMERS PRODUCED THEREFROM STERLING WINTHOP INC. (US) 1994-10-13 WO disclosed