Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIN1 | Q13526 | 8/20 | 0.71 |
| ▸ | MGMT | P16455 | 6/20 | 0.71 |
| ▸ | CDK1 | P06493 | 3/20 | 0.71 |
| ▸ | CCNB1 | P14635 | 3/20 | 0.71 |
| ▸ | CCNA2 | P20248 | 3/20 | 0.71 |
| ▸ | CDK2 | P24941 | 3/20 | 0.71 |
| ▸ | CCNA1 | P78396 | 3/20 | 0.71 |
| ▸ | LMNA | P02545 | 2/20 | 0.71 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.71 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.71 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.71 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.71 |
| ▸ | TSHR | P16473 | 1/20 | 0.71 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.71 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.71 |
| ▸ | BLM | P54132 | 1/20 | 0.71 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.71 |
| ▸ | CDC7 | O00311 | 3/20 | 0.63 |
| ▸ | DBF4 | Q9UBU7 | 3/20 | 0.63 |
| ▸ | HTR2C | P28335 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14542385 | 0.84 | PIN1 (0.72) | PIN1MGMTCDK1CCNB1CCNA2 | |
| SCHEMBL7437649 | 0.83 | PIN1 (0.71) | PIN1MGMTCDK1CCNB1CCNA2 | |
| 6-O-Benzylguanine SCHEMBL61740 | 0.83 | PIN1 (1.00) | PIN1MGMTCDK1CCNB1CCNA2 | |
| 6-O-Benzylguanine SCHEMBL31517079 | 0.83 | PIN1 (1.00) | PIN1MGMTCDK1CCNB1CCNA2 | |
| 6-O-Benzylguanine SCHEMBL4631744 | 0.82 | PIN1 (0.97) | PIN1MGMTCDK1CCNB1CCNA2 | |
| SCHEMBL3303850 | 0.80 | PIN1 (0.66) | PIN1MGMTCDK1CCNB1CCNA2 | |
| SCHEMBL15759317 | 0.79 | PIN1 (0.64) | PIN1MGMTCDK1CCNB1CCNA2 | |
| SCHEMBL1404475 | 0.78 | CDC7 (1.00) | PIN1MGMTCDK1CCNB1CCNA2 | |
| 6-O-Benzylguanine SCHEMBL4869639 | 0.78 | PIN1 (0.88) | PIN1MGMTCDK1CCNB1CCNA2 | |
| SCHEMBL8959020 | 0.77 | MGMT (0.46) | PIN1MGMTCDK1CCNB1CCNA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0523100-B1 | O6 -BENZYLATED GUANINE, GUANOSINE AND 2'-DEOXYGUANOSINE COMPOUNDS POSSESSING O6 -ALKYLGUANINE-DNA ALKYLTRANSFERASE DEPLETING ACTIVITY | US HEALTH (US) | 1996-08-28 | — | — | EP | disclosed |
| EP-0691981-A1 | TUMOR TARGETING WITH L-ENANTIOMERIC OLIGONUCLEOTIDE CONJUGATES OF IMMUNOREAGENTS AND OF CHELATED RADIONUCLIDES | THE WELLCOME FOUNDATION LIMITED (GB) | 1996-01-17 | — | — | EP | disclosed |
| WO-1994020523-A1 | TUMOR TARGETING WITH L-ENANTIOMERIC OLIGONUCLEOTIDE CONJUGATES OF IMMUNOREAGENTS AND OF CHELATED RADIONUCLIDES | THE WELLCOME FOUNDATION LIMITED (GB) | 1994-09-15 | — | — | WO | disclosed |