Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 6/20 | 0.57 |
| ▸ | ESR1 | P03372 | 5/20 | 0.57 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.57 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.57 |
| ▸ | ATM | Q13315 | 2/20 | 0.57 |
| ▸ | PGR | P06401 | 2/20 | 0.57 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.57 |
| ▸ | AR | P10275 | 1/20 | 0.57 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.57 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.57 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.57 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.57 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.55 |
| ▸ | MAPT | P10636 | 3/20 | 0.55 |
| ▸ | TP53 | P04637 | 1/20 | 0.55 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.46 |
| ▸ | THRB | P10828 | 1/20 | 0.46 |
| ▸ | RECQL | P46063 | 3/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9627648 | 0.89 | MAPT (0.59) | LMNAESR1SMN1; SMN2ADORA3ATM | |
| SCHEMBL9627957 | 0.88 | LMNA (0.56) | LMNAESR1SMN1; SMN2ADORA3ATM | |
| SCHEMBL9627672 | 0.87 | LMNA (0.55) | LMNAESR1SMN1; SMN2PGRSLC6A3 | |
| SCHEMBL8959345 | 0.86 | LMNA (0.58) | LMNAESR1SMN1; SMN2ADORA3ATM | |
| SCHEMBL9144814 | 0.86 | LMNA (0.58) | LMNAESR1SMN1; SMN2ADORA3ATM | |
| SCHEMBL9629474 | 0.85 | KMT2A (0.49) | LMNAESR1SMN1; SMN2ADORA3ATM | |
| SCHEMBL8959387 | 0.83 | SMN1; SMN2 (0.58) | LMNAESR1SMN1; SMN2ADORA3ATM | |
| SCHEMBL8938753 | 0.83 | LMNA (0.51) | LMNAESR1SMN1; SMN2PGRSLC6A3 | |
| SCHEMBL8206494 | 0.82 | STS (0.48) | LMNAESR1SMN1; SMN2CYP3A4MAPT | |
| SCHEMBL8206491 | 0.82 | STS (0.48) | LMNAESR1SMN1; SMN2CYP3A4MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0318490-B1 | 14,17-G(B)-ETHANO-14-G(B)-ESTRATRIENES, PROCESS FOR THEIR MANUFACTURE AND PHARMACEUTICAL PREPARATIONS CONTAINING THESE | SCHERING AKTIENGESELLSCHAFT (DE) | 1992-01-29 | — | — | EP | claimed |
| EP-0318490-B1 | 14,17-G(B)-ETHANO-14-G(B)-ESTRATRIENES, PROCESS FOR THEIR MANUFACTURE AND PHARMACEUTICAL PREPARATIONS CONTAINING THESE | SCHERING AKTIENGESELLSCHAFT (DE) | 1992-01-29 | — | — | EP | disclosed |