Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | CYP26A1 | O43174 | 4/20 | 0.41 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.41 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.40 |
| ▸ | HTR6 | P50406 | 1/20 | 0.39 |
| ▸ | CA1 | P00915 | 1/20 | 0.39 |
| ▸ | CA2 | P00918 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.39 |
| ▸ | PPM1D | O15297 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7329704 | 0.91 | MAPT (0.42) | MAPTMAPK1KCNK3HIF1AHTR6 | |
| SCHEMBL9318974 | 0.88 | CYP26A1 (0.44) | MAPTCYP26A1MEN1LMNACYP3A4 | |
| SCHEMBL7328034 | 0.80 | ALDH1A1 (0.42) | MAPTMAPK1CYP26A1KCNK3MEN1 | |
| SCHEMBL7356190 | 0.79 | CDC25B (0.43) | MAPTMEN1LMNACYP3A4CYP2C9 | |
| SCHEMBL7326911 | 0.78 | ROCK2 (0.44) | MAPTCYP26A1MEN1LMNACYP3A4 | |
| SCHEMBL7332244 | 0.76 | ALDH1A1 (0.41) | MAPTMEN1LMNACYP3A4CYP2C9 | |
| SCHEMBL5926345 | 0.75 | CYP26A1 (0.42) | MAPTMAPK1CYP26A1MEN1KMT2A | |
| SCHEMBL7326648 | 0.73 | ALDH1A1 (0.47) | MAPTCYP26A1MEN1LMNAKMT2A | |
| SCHEMBL7334505 | 0.71 | PPID (0.40) | MAPTHTR6CA1CA2MEN1 | |
| SCHEMBL13802920 | 0.69 | CASR (0.45) | MAPTCYP26A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0610334-B1 | NONPEPTIDYL INTEGRIN INHIBITORS HAVING SPECIFICITY FOR THE GPII B III A RECEPTOR | GENENTECH INC (US) | 1996-01-24 | — | — | EP | disclosed |
| EP-0610334-A1 | NONPEPTIDYL INTEGRIN INHIBITORS HAVING SPECIFICITY FOR THE GPII b?III a? RECEPTOR. | GENENTECH INC (US) | 1994-08-17 | — | — | EP | disclosed |