Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 9/20 | 0.40 |
| ▸ | HTR2A | P28223 | 8/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.37 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.37 |
| ▸ | HTR2B | P41595 | 1/20 | 0.37 |
| ▸ | THRA | P10827 | 1/20 | 0.32 |
| ▸ | THRB | P10828 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | APOBEC3A | P31941 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.32 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.32 |
| ▸ | AR | P10275 | 2/20 | 0.32 |
| ▸ | EIF4A3 | P38919 | 1/20 | 0.32 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8959608 | 0.89 | HTR2A (0.45) | HTR2CHTR2ACYP1A2CYP3A4CYP2C9 | |
| SCHEMBL8959561 | 0.85 | HTR2A (0.49) | HTR2CHTR2ACYP1A2CYP3A4CYP2C9 | |
| SCHEMBL27363223 | 0.85 | HTR2A (0.49) | HTR2CHTR2ACYP1A2CYP3A4CYP2C9 | |
| SCHEMBL8959713 | 0.85 | HTR2A (0.49) | HTR2CHTR2ACYP1A2CYP3A4CYP2C9 | |
| SCHEMBL8959551 | 0.84 | AR (0.39) | HTR2CHTR2ACYP1A2CYP3A4CYP2C9 | |
| SCHEMBL8959864 | 0.83 | HTR2A (0.49) | HTR2CHTR2ACYP1A2CYP3A4CYP2C9 | |
| SCHEMBL8959678 | 0.81 | HTR2C (0.46) | HTR2CHTR2AARNPY5R | |
| SCHEMBL8959562 | 0.81 | HTR2C (0.46) | HTR2CHTR2AARNPY5R | |
| SCHEMBL8959479 | 0.81 | HTR2C (0.46) | HTR2CHTR2AARNPY5R | |
| SCHEMBL27356666 | 0.81 | HTR2C (0.46) | HTR2CHTR2AARNPY5R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5494928-A | FOR CENTRAL NERVOUS SYSTEM DISORDERS, BLOCKING SEROTONIN RECEPTORS, ANTIDEPRESSANTS | HOFFMANN-LA ROCHE INC. (US) | 1996-02-27 | — | — | US | disclosed |