Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 3/20 | 0.46 |
| ▸ | HTR2A | P28223 | 2/20 | 0.46 |
| ▸ | AR | P10275 | 5/20 | 0.43 |
| ▸ | FABP4 | P15090 | 1/20 | 0.38 |
| ▸ | PPARG | P37231 | 3/20 | 0.38 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.35 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.35 |
| ▸ | CDK4 | P11802 | 1/20 | 0.35 |
| ▸ | CCND1 | P24385 | 1/20 | 0.35 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.35 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.35 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.35 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.35 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8959479 | 1.00 | HTR2C (0.46) | HTR2CHTR2AARFABP4PPARG | |
| SCHEMBL8959562 | 0.91 | HTR2C (0.46) | HTR2CHTR2AARFABP4PPARG | |
| SCHEMBL27356666 | 0.91 | HTR2C (0.46) | HTR2CHTR2AARFABP4PPARG | |
| SCHEMBL8959547 | 0.87 | HTR2C (0.45) | HTR2CHTR2AFABP4CDK4CCND1 | |
| SCHEMBL8959608 | 0.87 | HTR2A (0.45) | HTR2CHTR2AARGRIN2BNPY5R | |
| SCHEMBL27342171 | 0.87 | HTR2C (0.45) | HTR2CHTR2AFABP4CDK4CCND1 | |
| SCHEMBL8959572 | 0.86 | HTR2C (0.44) | HTR2CHTR2AARFABP4PPARG | |
| SCHEMBL8959588 | 0.86 | HTR2A (0.46) | HTR2CHTR2AARNPY5RCDK4 | |
| SCHEMBL27524962 | 0.86 | HTR2A (0.46) | HTR2CHTR2AARNPY5RCDK4 | |
| SCHEMBL27340857 | 0.86 | HTR2A (0.46) | HTR2CHTR2AARFABP4HDAC3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1061341-C | 1-amino-ethylindole-derivatives | HOFFMANN LA ROCHE (CH) | 2001-01-31 | — | — | CN | disclosed |
| US-5494928-A | FOR CENTRAL NERVOUS SYSTEM DISORDERS, BLOCKING SEROTONIN RECEPTORS, ANTIDEPRESSANTS | HOFFMANN-LA ROCHE INC. (US) | 1996-02-27 | — | — | US | disclosed |
| CN-1105988-A | 1-amino-ethylindole-derivatives | HOFFMANN LA ROCHE (CH) | 1995-08-02 | — | — | CN | disclosed |