Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 3/20 | 0.46 |
| ▸ | HTR2A | P28223 | 2/20 | 0.46 |
| ▸ | AR | P10275 | 5/20 | 0.43 |
| ▸ | HTR7 | P34969 | 1/20 | 0.38 |
| ▸ | CNR1 | P21554 | 2/20 | 0.36 |
| ▸ | FABP4 | P15090 | 1/20 | 0.36 |
| ▸ | PPARG | P37231 | 1/20 | 0.36 |
| ▸ | PPARD | Q03181 | 1/20 | 0.36 |
| ▸ | PPARA | Q07869 | 1/20 | 0.36 |
| ▸ | NR3C1 | P04150 | 1/20 | 0.36 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.35 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.35 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27356666 | 1.00 | HTR2C (0.46) | HTR2CHTR2AARHTR7CNR1 | |
| SCHEMBL8959678 | 0.91 | HTR2C (0.46) | HTR2CHTR2AARFABP4PPARG | |
| SCHEMBL8959479 | 0.91 | HTR2C (0.46) | HTR2CHTR2AARFABP4PPARG | |
| SCHEMBL27528051 | 0.87 | HTR2A (0.45) | HTR2CHTR2AHTR7FABP4MTNR1A | |
| SCHEMBL8959608 | 0.87 | HTR2A (0.45) | HTR2CHTR2AARMTNR1AMTNR1B | |
| SCHEMBL8959581 | 0.87 | HTR2A (0.45) | HTR2CHTR2AHTR7FABP4MTNR1A | |
| SCHEMBL7997832 | 0.86 | KMO (0.48) | HTR2CHTR2AARHTR7PPARG | |
| SCHEMBL8959864 | 0.83 | HTR2A (0.49) | HTR2CHTR2AAR | |
| SCHEMBL8959561 | 0.83 | HTR2A (0.49) | HTR2CHTR2AAR | |
| SCHEMBL8959713 | 0.83 | HTR2A (0.49) | HTR2CHTR2AAR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5494928-A | FOR CENTRAL NERVOUS SYSTEM DISORDERS, BLOCKING SEROTONIN RECEPTORS, ANTIDEPRESSANTS | HOFFMANN-LA ROCHE INC. (US) | 1996-02-27 | — | — | US | disclosed |