Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ICMT | O60725 | 7/20 | 0.48 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.43 |
| ▸ | CRY2 | Q49AN0 | 9/20 | 0.42 |
| ▸ | PER2 | O15055 | 8/20 | 0.42 |
| ▸ | CRY1 | Q16526 | 6/20 | 0.42 |
| ▸ | HTR3A | P46098 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8959663 | 1.00 | ICMT (0.48) | ICMTSCN9AKCNH2CRY2PER2 | |
| SCHEMBL9234058 | 0.86 | HTR2C (0.54) | ICMTKCNH2 | |
| SCHEMBL8959518 | 0.82 | PER2 (0.40) | ICMTSCN9ACRY2PER2CRY1 | |
| SCHEMBL8959520 | 0.82 | PER2 (0.40) | ICMTSCN9ACRY2PER2CRY1 | |
| Fumaric Acid SCHEMBL27342763 | 0.80 | ICMT (0.48) | ICMTHTR3A | |
| SCHEMBL8959510 | 0.78 | ICMT (0.45) | ICMTKCNH2 | |
| SCHEMBL8959513 | 0.78 | ICMT (0.45) | ICMTKCNH2 | |
| SCHEMBL22647112 | 0.76 | KCNH2 (0.47) | ICMTKCNH2CRY2PER2CRY1 | |
| SCHEMBL13131357 | 0.74 | ICMT (0.60) | ICMTKCNH2 | |
| SCHEMBL18508879 | 0.73 | KDM4E (0.58) | ICMTKCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1061341-C | 1-amino-ethylindole-derivatives | HOFFMANN LA ROCHE (CH) | 2001-01-31 | — | — | CN | disclosed |
| US-5494928-A | FOR CENTRAL NERVOUS SYSTEM DISORDERS, BLOCKING SEROTONIN RECEPTORS, ANTIDEPRESSANTS | HOFFMANN-LA ROCHE INC. (US) | 1996-02-27 | — | — | US | disclosed |
| CN-1105988-A | 1-amino-ethylindole-derivatives | HOFFMANN LA ROCHE (CH) | 1995-08-02 | — | — | CN | disclosed |
| EP-0655440-A2 | 1-Aminoethylindoles | F. HOFFMANN-LA ROCHE AG (CH) | 1995-05-31 | — | — | EP | disclosed |