Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 2/20 | 0.62 |
| ▸ | DRD4 | P21917 | 2/20 | 0.62 |
| ▸ | DRD3 | P35462 | 2/20 | 0.62 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.56 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.54 |
| ▸ | MAPT | P10636 | 5/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.54 |
| ▸ | HPGD | P15428 | 4/20 | 0.54 |
| ▸ | MEN1 | O00255 | 3/20 | 0.54 |
| ▸ | LMNA | P02545 | 1/20 | 0.54 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.54 |
| ▸ | NPC1 | O15118 | 2/20 | 0.53 |
| ▸ | RAB9A | P51151 | 2/20 | 0.53 |
| ▸ | TP53 | P04637 | 1/20 | 0.53 |
| ▸ | GAA | P10253 | 1/20 | 0.53 |
| ▸ | HTR6 | P50406 | 2/20 | 0.51 |
| ▸ | CNR1 | P21554 | 2/20 | 0.51 |
| ▸ | NQO2 | P16083 | 1/20 | 0.51 |
| ▸ | HTR1A | P08908 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3276549 | 0.88 | DRD2 (0.59) | DRD2DRD4DRD3KMT2AALDH1A1 | |
| SCHEMBL7511884 | 0.88 | DRD2 (0.61) | DRD2DRD4DRD3KMT2AALDH1A1 | |
| SCHEMBL13906461 | 0.86 | ALDH1A1 (0.56) | DRD2DRD4DRD3KMT2AALDH1A1 | |
| SCHEMBL16943501 | 0.86 | ALDH1A1 (0.71) | DRD2DRD4DRD3KMT2AALDH1A1 | |
| SCHEMBL24375425 | 0.86 | KMT2A (0.58) | DRD2DRD4DRD3KMT2AALDH1A1 | |
| SCHEMBL3283431 | 0.86 | ALDH1A1 (0.69) | DRD2DRD4DRD3KMT2AALDH1A1 | |
| SCHEMBL6953058 | 0.85 | DRD2 (0.58) | DRD2DRD4DRD3KMT2AALDH1A1 | |
| SCHEMBL16747008 | 0.85 | ALDH1A1 (0.61) | DRD2DRD4DRD3KMT2AALDH1A1 | |
| SCHEMBL12496609 | 0.84 | ALDH1A1 (0.66) | KMT2AALDH1A1KDM4EMAPTSMN1; SMN2 | |
| SCHEMBL2204971 | 0.84 | KMT2A (0.56) | DRD2DRD4DRD3KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5494928-A | FOR CENTRAL NERVOUS SYSTEM DISORDERS, BLOCKING SEROTONIN RECEPTORS, ANTIDEPRESSANTS | HOFFMANN-LA ROCHE INC. (US) | 1996-02-27 | — | — | US | disclosed |