Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DRD2 | P14416 | 2/20 | 0.59 |
| ▸ | DRD4 | P21917 | 2/20 | 0.59 |
| ▸ | DRD3 | P35462 | 2/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.52 |
| ▸ | MAPT | P10636 | 5/20 | 0.52 |
| ▸ | HPGD | P15428 | 5/20 | 0.52 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | LMNA | P02545 | 2/20 | 0.52 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.52 |
| ▸ | NPC1 | O15118 | 2/20 | 0.50 |
| ▸ | RAB9A | P51151 | 2/20 | 0.50 |
| ▸ | TP53 | P04637 | 2/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.48 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.48 |
| ▸ | NQO2 | P16083 | 1/20 | 0.48 |
| ▸ | HTR6 | P50406 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7511884 | 0.90 | DRD2 (0.61) | DRD2DRD4DRD3KMT2AALDH1A1 | |
| SCHEMBL8959676 | 0.88 | DRD2 (0.62) | DRD2DRD4DRD3KMT2AALDH1A1 | |
| SCHEMBL27195463 | 0.87 | ALDH1A1 (0.66) | DRD2DRD4DRD3KMT2AALDH1A1 | |
| SCHEMBL1191675 | 0.86 | KDM4E (0.51) | DRD2DRD4DRD3KMT2AALDH1A1 | |
| SCHEMBL3958468 | 0.84 | ALDH1A1 (0.71) | KMT2AALDH1A1KDM4EMAPTHPGD | |
| SCHEMBL29628777 | 0.84 | ALDH1A1 (0.71) | KMT2AALDH1A1KDM4EMAPTHPGD | |
| SCHEMBL17674200 | 0.84 | KDM4E (0.45) | DRD2DRD4DRD3KMT2AALDH1A1 | |
| SCHEMBL24375425 | 0.83 | KMT2A (0.58) | DRD2DRD4DRD3KMT2AALDH1A1 | |
| SCHEMBL3283431 | 0.83 | ALDH1A1 (0.69) | DRD2DRD4DRD3KMT2AALDH1A1 | |
| SCHEMBL6953058 | 0.82 | DRD2 (0.58) | DRD2DRD4DRD3KMT2AALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1966134-B1 | NOVEL FUSED PYRROLE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2014-03-12 | — | — | EP | disclosed |
| US-7696240-B2 | Fused pyrrole derivatives | HOFFMANN-LA ROCHE INC. (US) | 2010-04-13 | — | — | US | disclosed |
| EP-1966134-A1 | NOVEL FUSED PYRROLE DERIVATIVES | F.HOFFMANN-LA ROCHE AG (CH) | 2008-09-10 | — | — | EP | disclosed |
| WO-2007068621-A1 | NOVEL FUSED PYRROLE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2007-06-21 | — | — | WO | disclosed |
| US-20070142452-A1 | Fused pyrrole derivatives | HOFFMANN-LA ROCHE INC. | 2007-06-21 | — | — | US | disclosed |
| CN-1089765-C | 1H-pyrido [3,4-b] indole-4-carboxamide derivatives, preparation and application thereof in therapeutics | SANOFI SYNTHESIZING LAB (FR) | 2002-08-28 | — | — | CN | disclosed |
| US-6075021-A | 1H-pyrido[3,4-b]indole-4-carboxamide derivatives, preparation and application thereof in therapeutics | SYNTHELABO (FR) | 2000-06-13 | — | — | US | disclosed |
| CN-1233248-A | 1H-pyrido [3,4-b] indole-4-carboxamide derivatives, preparation and application thereof in therapeutics | SYNTHELABO (FR) | 1999-10-27 | — | — | CN | disclosed |
| US-5229413-A | Nervous system disorders | G. D. SEARLE & CO. (US) | 1993-07-20 | — | — | US | disclosed |
| US-5137910-A | Compositions containing indole-2-carboxylate compounds for treatment of CNS disorders | C.D. SEARLE & CO. (US) | 1992-08-11 | — | — | US | disclosed |
| EP-0396124-A2 | Compositions containing indole-2-carboxylate compounds for treatment of CNS disorders | G.D. Searle & Co. (US) | 1990-11-07 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070142452-A1 | Fused pyrrole derivatives | CMA1, PREP, CPA3 | DRD2 1472/4885DRD4 1931/4885DRD3 1342/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.