Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 3/20 | 0.58 |
| ▸ | HPGD | P15428 | 1/20 | 0.58 |
| ▸ | GABRA1 | P14867 | 5/20 | 0.47 |
| ▸ | GABRB2 | P47870 | 5/20 | 0.47 |
| ▸ | CTNNB1 | P35222 | 4/20 | 0.43 |
| ▸ | WNT3A | P56704 | 4/20 | 0.43 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.41 |
| ▸ | HAT1 | O14929 | 2/20 | 0.40 |
| ▸ | EP300 | Q09472 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9289530 | 0.94 | MAPT (0.56) | MAPTHPGDGABRA1GABRB2CTNNB1 | |
| SCHEMBL8959773 | 0.83 | MAPT (0.58) | MAPTHPGDGABRA1GABRB2CTNNB1 | |
| SCHEMBL8959890 | 0.83 | MAPT (0.57) | MAPTHPGDGABRA1GABRB2CTNNB1 | |
| SCHEMBL8959856 | 0.83 | MAPT (0.51) | MAPTHPGDGABRA1GABRB2MEN1 | |
| SCHEMBL8959862 | 0.83 | MAPT (0.51) | MAPTHPGDGABRA1GABRB2MEN1 | |
| SCHEMBL9289534 | 0.79 | ALOX12 (0.43) | MAPTHPGDMEN1KMT2ACYP2C19 | |
| SCHEMBL8959729 | 0.79 | MAPT (0.57) | MAPTHPGDGABRA1GABRB2CTNNB1 | |
| SCHEMBL8960173 | 0.77 | PTGS1 (0.46) | LMNACYP2C9 | |
| SCHEMBL8959823 | 0.77 | MAPT (0.57) | MAPTHPGDGABRA1GABRB2CTNNB1 | |
| SCHEMBL8959873 | 0.76 | MAPT (0.61) | MAPTHPGDGABRA1GABRB2CTNNB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5530019-A | FOR TREATMENT OF PROSTATE GLAND DISORDERS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1996-06-25 | — | — | US | disclosed |
| EP-0648208-A1 | INDOLE DERIVATIVES AS TESTOSTERONE 5 ALPHA-REDUCTASE INHIBITORS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1995-04-19 | — | — | EP | disclosed |
| WO-1994022821-A1 | INDOLE DERIVATIVES AS TESTOSTERONE 5 ALPHA-REDUCTASE INHIBITORS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1994-10-13 | — | — | WO | disclosed |