Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.61 |
| ▸ | HPGD | P15428 | 1/20 | 0.61 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.53 |
| ▸ | CTNNB1 | P35222 | 5/20 | 0.53 |
| ▸ | WNT3A | P56704 | 5/20 | 0.53 |
| ▸ | GABRA1 | P14867 | 3/20 | 0.51 |
| ▸ | GABRB2 | P47870 | 3/20 | 0.51 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | IGF1R | P08069 | 1/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | HAT1 | O14929 | 2/20 | 0.47 |
| ▸ | EP300 | Q09472 | 2/20 | 0.47 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.46 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.46 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.46 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.46 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.46 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8959823 | 0.88 | MAPT (0.57) | MAPTHPGDADAM17CTNNB1WNT3A | |
| SCHEMBL8959773 | 0.83 | MAPT (0.58) | MAPTHPGDADAM17CTNNB1WNT3A | |
| SCHEMBL8959729 | 0.82 | MAPT (0.57) | MAPTHPGDADAM17CTNNB1WNT3A | |
| SCHEMBL8959890 | 0.82 | MAPT (0.57) | MAPTHPGDADAM17CTNNB1WNT3A | |
| SCHEMBL9289530 | 0.79 | MAPT (0.56) | MAPTHPGDADAM17CTNNB1WNT3A | |
| SCHEMBL1563151 | 0.78 | GABRA1 (0.74) | MAPTADAM17CTNNB1WNT3AGABRA1 | |
| SCHEMBL8959745 | 0.78 | ADAM17 (0.66) | MAPTHPGDADAM17CTNNB1WNT3A | |
| SCHEMBL8959876 | 0.77 | SLC6A4 (0.54) | MAPTHPGDALDH1A1KMT2A | |
| SCHEMBL8077164 | 0.77 | GABRA1 (0.72) | MAPTADAM17CTNNB1WNT3AGABRA1 | |
| SCHEMBL8959628 | 0.77 | GABRA1 (0.72) | MAPTADAM17CTNNB1WNT3AGABRA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5530019-A | FOR TREATMENT OF PROSTATE GLAND DISORDERS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1996-06-25 | — | — | US | disclosed |
| EP-0648208-A1 | INDOLE DERIVATIVES AS TESTOSTERONE 5 ALPHA-REDUCTASE INHIBITORS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1995-04-19 | — | — | EP | disclosed |
| WO-1994022821-A1 | INDOLE DERIVATIVES AS TESTOSTERONE 5 ALPHA-REDUCTASE INHIBITORS | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1994-10-13 | — | — | WO | disclosed |