Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP4F2 | P78329 | 1/20 | 0.38 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.38 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | EP300 | Q09472 | 1/20 | 0.31 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.31 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.30 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.30 |
| ▸ | NPC1 | O15118 | 2/20 | 0.30 |
| ▸ | RAB9A | P51151 | 2/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | ESR1 | P03372 | 1/20 | 0.30 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.30 |
| ▸ | ITGA2B | P08514 | 1/20 | 0.30 |
| ▸ | HMGB1 | P09429 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | TSHR | P16473 | 1/20 | 0.30 |
| ▸ | GGT1 | P19440 | 1/20 | 0.30 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8959947 | 0.87 | NOTUM (0.37) | NOTUMMEN1KMT2AKDM4ENPC1 | |
| SCHEMBL32691742 | 0.83 | NOTUM (0.36) | NOTUMKDM4ETDP1NPC1RAB9A | |
| SCHEMBL3564119 | 0.81 | NOTUM (0.41) | NOTUMMEN1KMT2AEP300CREBBP | |
| SCHEMBL28977332 | 0.80 | CYP4F2 (0.37) | CYP4F2CYP4A11NOTUMKMT2AEP300 | |
| SCHEMBL28977327 | 0.77 | NOTUM (0.48) | NOTUMMEN1KMT2AKDM4ETDP1 | |
| SCHEMBL27363222 | 0.76 | NOTUM (0.37) | NOTUMMEN1KMT2AEP300CREBBP | |
| SCHEMBL2476989 | 0.74 | ABCB11 (0.46) | NOTUMMEN1KMT2AKDM4ETDP1 | |
| SCHEMBL28977329 | 0.71 | EGFR (0.37) | NOTUMKMT2AKDM4ETDP1NPC1 | |
| SCHEMBL3241798 | 0.71 | ABCB11 (0.46) | NOTUMMEN1KMT2ACREBBPKDM4E | |
| SCHEMBL8959923 | 0.71 | KDM4E (0.37) | CYP4F2CYP4A11NOTUMCREBBPKDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1061341-C | 1-amino-ethylindole-derivatives | HOFFMANN LA ROCHE (CH) | 2001-01-31 | — | — | CN | disclosed |
| US-5494928-A | FOR CENTRAL NERVOUS SYSTEM DISORDERS, BLOCKING SEROTONIN RECEPTORS, ANTIDEPRESSANTS | HOFFMANN-LA ROCHE INC. (US) | 1996-02-27 | — | — | US | disclosed |
| CN-1105988-A | 1-amino-ethylindole-derivatives | HOFFMANN LA ROCHE (CH) | 1995-08-02 | — | — | CN | disclosed |