Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ABCB11 | O95342 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.41 |
| ▸ | MEN1 | O00255 | 4/20 | 0.41 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.38 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.38 |
| ▸ | NPC1 | O15118 | 2/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.38 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.38 |
| ▸ | ATM | Q13315 | 1/20 | 0.38 |
| ▸ | BAZ2B | Q9UIF8 | 1/20 | 0.38 |
| ▸ | HPGD | P15428 | 3/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 2/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3241798 | 0.88 | ABCB11 (0.46) | ABCB11KMT2AMEN1NOTUMKDM4E | |
| SCHEMBL17320137 | 0.84 | BAZ2B (0.42) | KMT2AMEN1NOTUMKDM4EMAPT | |
| SCHEMBL13834151 | 0.84 | NPC1 (0.42) | NOTUMMAPTNPSR1NPC1RAB9A | |
| SCHEMBL8959923 | 0.82 | KDM4E (0.37) | NOTUMKDM4EMAPTNPSR1NPC1 | |
| SCHEMBL22415249 | 0.82 | MTNR1A (0.36) | NOTUMKDM4EMAPTNPSR1NPC1 | |
| SCHEMBL2470098 | 0.82 | LMNA (0.40) | NOTUMKDM4ERAB9ABAZ2BHPGD | |
| SCHEMBL29507033 | 0.82 | LMNA (0.40) | NOTUMKDM4ERAB9ABAZ2BHPGD | |
| SCHEMBL13172044 | 0.81 | MTNR1A (0.55) | KDM4EMAPTRAB9ABAZ2BHPGD | |
| SCHEMBL2475378 | 0.78 | NOTUM (0.45) | KMT2AMEN1NOTUMKCNH2KDM4E | |
| SCHEMBL1051164 | 0.78 | CREBBP (0.50) | KMT2AMEN1KDM4EMAPTNPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115894330-A | Synthesis method and application of 1-acetyl-1H-indol-3-yl acetate derivative | 吉林医药学院 | 2023-04-04 | — | — | CN | disclosed |
| EP-2531488-B1 | INDIRUBIN-3'-OXIME DERIVATIVES AS POTENT CYCLIN DEPENDENT KINASE INHIBITORS | ANYGEN CO LTD (KR) | 2015-12-09 | — | — | EP | disclosed |
| EP-2531488-B1 | INDIRUBIN-3'-OXIME DERIVATIVES AS POTENT CYCLIN DEPENDENT KINASE INHIBITORS | ANYGEN CO LTD (KR) | 2015-12-09 | — | — | EP | disclosed |
| US-8859783-B2 | Indirubin-3′-oxime derivatives as potent cyclin dependent kinase inhibitors | ANYGEN CO., LTD. (KR) | 2014-10-14 | — | — | US | disclosed |
| US-8859783-B2 | Indirubin-3′-oxime derivatives as potent cyclin dependent kinase inhibitors | ANYGEN CO., LTD. (KR) | 2014-10-14 | — | — | US | disclosed |
| US-8642765-B2 | Azaindole-indole coupled derivatives, preparation methods and uses thereof | Cheng, Jingcai (CN) | 2014-02-04 | — | — | US | disclosed |
| US-20120295948-A1 | INDIRUBIN-3'-OXIME DERIVATIVES AS POTENT CYCLIN DEPENDENT KINASE INHIBITORS | ANYGEN CO., LTD. (KR) | 2012-11-22 | — | — | US | disclosed |
| CN-101715452-B | Azaindole-indole coupled derivatives, preparation methods and uses thereof | JINGCAI CHENG | 2012-10-10 | — | — | CN | disclosed |
| EP-2168964-B1 | AZAINDOLE-INDOLE COUPLED DERIVATIVES, PREPARATION METHODS AND USES THEREOF | CHENG JINGCAI (CN) | 2011-10-12 | — | — | EP | disclosed |
| US-20100137356-A1 | AZAINDOLE-INDOLE COUPLED DERIVATIVES, PREPARATION METHODS AND USES THEREOF | Cheng, Jingcai (CN) | 2010-06-03 | — | — | US | disclosed |
| EP-2168964-A1 | AZAINDOLE-INDOLE COUPLED DERIVATIVES, PREPARATION METHODS AND USES THEREOF | Cheng, Jingcai (CN) | 2010-03-31 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100137356-A1 | AZAINDOLE-INDOLE COUPLED DERIVATIVES, PREPARATION METHODS AND USES THEREOF | IDO1, IDO2, INMT | ABCB11 1641/4885KMT2A 1417/4885MEN1 3112/4885 |
| US-20120295948-A1 | INDIRUBIN-3'-OXIME DERIVATIVES AS POTENT CYCLIN DEPENDENT KINASE INHIBITORS | CCNI, CCNK, CDK2 | ABCB11 4492/4885KMT2A 488/4885MEN1 4241/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.