SCHEMBL8960181

SCHEMBL8960181

O=C1COc2cc(F)c(-n3cnc(C(F)(F)F)c(Cl)c3=O)cc2N1

nearest known ligand 0.39

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
NR3C2 P08235 12/20 0.39
NR3C1 P04150 2/20 0.36
PGR P06401 2/20 0.36
MCL1 Q07820 1/20 0.35
TP53 P04637 2/20 0.35
KIF11 P52732 1/20 0.35
POLB P06746 1/20 0.34
MEN1 O00255 2/20 0.34
KMT2A Q03164 2/20 0.34
MAPT P10636 1/20 0.34
THRB P10828 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8960113 0.85 NR3C2 (0.41) NR3C2NR3C1PGRTP53POLB
SCHEMBL8960539 0.75 EGFR (0.31)
SCHEMBL6726966 0.74 NR3C2 (0.38) NR3C2PGRMCL1KIF11POLB
SCHEMBL9603358 0.72 KIF11 (0.47) NR3C2NR3C1PGRMCL1KIF11
SCHEMBL10362097 0.70 NR3C2 (0.42) NR3C2NR3C1PGRTP53MEN1
SCHEMBL8960124 0.69 ESR2 (0.54) POLB
SCHEMBL10491107 0.69 MAPT (0.46) NR3C2TP53MEN1KMT2AMAPT
SCHEMBL30557601 0.69 ACLY (0.49) NR3C2TP53POLBMEN1KMT2A
SCHEMBL12067736 0.69 ACLY (0.49) NR3C2TP53POLBMEN1KMT2A
SCHEMBL7563867 0.68 NR3C2 (0.39) NR3C2NR3C1PGRTP53KIF11

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5532208-A HERBICIDES SUMITOMO CHEMICAL CO., LTD. (JP) 1996-07-02 US disclosed
US-5366955-A HERBICIDES SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1994-11-22 US disclosed
EP-0568041-A1 Pyrimidone derivatives and their use SUMITOMO CHEMICAL COMPANY, LIMITED (JP) 1993-11-03 EP disclosed