Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | PLG | P00747 | 2/20 | 0.35 |
| ▸ | F10 | P00742 | 1/20 | 0.35 |
| ▸ | PLAU | P00749 | 1/20 | 0.35 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.35 |
| ▸ | BCHE | P06276 | 2/20 | 0.32 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.31 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.31 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.31 |
| ▸ | CASP3 | P42574 | 1/20 | 0.30 |
| ▸ | TLR2 | O60603 | 1/20 | 0.30 |
| ▸ | TLR1 | Q15399 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2366956 | 0.86 | MDM2 (0.42) | PLGF10PLAUKLKB1CASP3 | |
| SCHEMBL29469785 | 0.86 | MDM2 (0.42) | PLGF10PLAUKLKB1CASP3 | |
| SCHEMBL2367323 | 0.86 | MDM2 (0.42) | PLGF10PLAUKLKB1CASP3 | |
| SCHEMBL4094903 | 0.85 | PLG (0.37) | KMT2APLGF10PLAUKLKB1 | |
| SCHEMBL14374808 | 0.85 | PLG (0.36) | KMT2APLGF10PLAUKLKB1 | |
| SCHEMBL4430880 | 0.85 | CASP3 (0.39) | KMT2APLGF10PLAUKLKB1 | |
| SCHEMBL2367324 | 0.83 | PLG (0.37) | KMT2APLGF10PLAUKLKB1 | |
| SCHEMBL2366962 | 0.83 | PLG (0.37) | KMT2APLGF10PLAUKLKB1 | |
| SCHEMBL12214883 | 0.81 | PLG (0.34) | KMT2APLGF10PLAUKLKB1 | |
| SCHEMBL8260151 | 0.81 | PLG (0.34) | KMT2APLGF10PLAUKLKB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0693081-A1 | CYCLIC COMPOUNDS AND COMPOSITIONS WHICH INHIBIT BONE RESORPTION | Novartis AG (CH) | 1996-01-24 | — | — | EP | disclosed |
| WO-1994024153-A1 | CYCLIC COMPOUNDS AND COMPOSITIONS WHICH INHIBIT BONE RESORPTION | CIBA-GEIGY AG (CH) | 1994-10-27 | — | — | WO | disclosed |