Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLG | P00747 | 3/20 | 0.42 |
| ▸ | PLAU | P00749 | 2/20 | 0.42 |
| ▸ | F10 | P00742 | 1/20 | 0.42 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.42 |
| ▸ | ALOX5 | P09917 | 3/20 | 0.36 |
| ▸ | F2 | P00734 | 2/20 | 0.34 |
| ▸ | ST14 | Q9Y5Y6 | 1/20 | 0.34 |
| ▸ | BCHE | P06276 | 8/20 | 0.33 |
| ▸ | ACHE | P22303 | 8/20 | 0.33 |
| ▸ | OPRL1 | P41146 | 1/20 | 0.32 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.32 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL850468 | 0.84 | PLG (0.45) | PLGPLAUF10KLKB1ALOX5 | |
| SCHEMBL8961190 | 0.83 | PLG (0.40) | PLGPLAUF10KLKB1F2 | |
| SCHEMBL8961328 | 0.82 | PLG (0.38) | PLGPLAUF10KLKB1ALOX5 | |
| SCHEMBL8961420 | 0.81 | KMT2A (0.38) | PLGPLAUF10KLKB1BCHE | |
| SCHEMBL8112581 | 0.77 | PLG (0.40) | PLGPLAUF10KLKB1F2 | |
| SCHEMBL18506897 | 0.77 | PLG (0.41) | PLGPLAUF10KLKB1F2 | |
| SCHEMBL4430680 | 0.77 | PLG (0.44) | PLGPLAUF10KLKB1F2 | |
| SCHEMBL4438826 | 0.77 | SIRT2 (0.44) | PLGPLAUF10KLKB1 | |
| SCHEMBL4428219 | 0.77 | PLG (0.41) | PLGPLAUF10KLKB1ALOX5 | |
| SCHEMBL4437400 | 0.77 | PLG (0.41) | PLGPLAUF10KLKB1ALOX5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0693081-A1 | CYCLIC COMPOUNDS AND COMPOSITIONS WHICH INHIBIT BONE RESORPTION | Novartis AG (CH) | 1996-01-24 | — | — | EP | disclosed |
| WO-1994024153-A1 | CYCLIC COMPOUNDS AND COMPOSITIONS WHICH INHIBIT BONE RESORPTION | CIBA-GEIGY AG (CH) | 1994-10-27 | — | — | WO | disclosed |