Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | ESR1 | P03372 | 2/20 | 0.38 |
| ▸ | ESR2 | Q92731 | 2/20 | 0.38 |
| ▸ | GAA | P10253 | 2/20 | 0.38 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | RAPGEF4 | Q8WZA2 | 1/20 | 0.35 |
| ▸ | TSHR | P16473 | 1/20 | 0.34 |
| ▸ | CA2 | P00918 | 3/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | HTR6 | P50406 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3620171 | 0.95 | KMT2A (0.41) | MEN1KMT2AESR1ESR2GAA | |
| SCHEMBL8654494 | 0.88 | KMT2A (0.45) | MEN1KMT2AESR1ESR2GAA | |
| SCHEMBL15995052 | 0.86 | GAA (0.44) | MEN1KMT2AESR1ESR2GAA | |
| SCHEMBL7285964 | 0.84 | ALDH1A1 (0.44) | MEN1KMT2AESR1ESR2GAA | |
| SCHEMBL25199151 | 0.83 | POLB (0.41) | MEN1KMT2AESR1ESR2GAA | |
| SCHEMBL28631020 | 0.82 | CYP1A2 (0.41) | MEN1KMT2AESR1ESR2GAA | |
| SCHEMBL6913134 | 0.81 | TSHR (0.41) | MEN1KMT2AESR1ESR2GAA | |
| SCHEMBL7619544 | 0.81 | KMT2A (0.43) | MEN1KMT2AESR1ESR2GAA | |
| SCHEMBL19570349 | 0.81 | MEN1 (0.36) | MEN1KMT2AESR1ESR2GAA | |
| SCHEMBL28940101 | 0.81 | POLB (0.42) | MEN1KMT2AESR1ESR2GAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5502187-A | Pharmaceutically active bicyclic-heterocyclic amines | THE UPJOHN COMPANY (US) | 1996-03-26 | — | — | US | disclosed |
| EP-0633886-A1 | PHARMACEUTICALLY ACTIVE BICYCLIC-HETEROCYCLIC AMINES | PHARMACIA & UPJOHN COMPANY (US) | 1995-01-18 | — | — | EP | disclosed |
| WO-1993020078-A1 | PHARMACEUTICALLY ACTIVE BICYCLIC-HETEROCYCLIC AMINES | THE UPJOHN COMPANY (US) | 1993-10-14 | — | — | WO | disclosed |