Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Adipic Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 known ✓ | P23975 | 1/20 | 0.45 |
| ▸ | SLC6A3 known ✓ | Q01959 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | NFKB1 | P19838 | 2/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 4/20 | 0.45 |
| ▸ | BLM | P54132 | 2/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.45 |
| ▸ | THRB | P10828 | 2/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | PLG | P00747 | 1/20 | 0.45 |
| ▸ | RECQL | P46063 | 1/20 | 0.45 |
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | GABRR3 | A8MPY1 | 1/20 | 0.43 |
| ▸ | GABRP | O00591 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Adipic Acid SCHEMBL8433509 | 1.00 | CYP1A2 (0.47) | CYP1A2MAPK1SMN1; SMN2NFKB1CYP2D6 | |
| Adipic Acid SCHEMBL2687853 | 0.91 | CYP1A2 (0.50) | CYP1A2MAPK1SMN1; SMN2NFKB1CYP2D6 | |
| SCHEMBL8859810 | 0.87 | L3MBTL1 (0.46) | SMN1; SMN2LMNAKMT2AALOX15MEN1 | |
| SCHEMBL5865021 | 0.87 | CYP1A2 (0.57) | CYP1A2MAPK1SMN1; SMN2NFKB1LMNA | |
| Glycine SCHEMBL21810684 | 0.87 | ALOX15 (0.46) | SMN1; SMN2LMNAKMT2AALOX15MEN1 | |
| SCHEMBL27793739 | 0.87 | CYP1A2 (0.57) | CYP1A2MAPK1SMN1; SMN2NFKB1LMNA | |
| Adipic Acid SCHEMBL21641808 | 0.87 | ALOX15 (0.56) | CYP1A2MAPK1SMN1; SMN2NFKB1CYP2D6 | |
| Bicarbonate SCHEMBL16668577 | 0.87 | ALOX15 (0.50) | SMN1; SMN2LMNAKMT2AALOX15MEN1 | |
| SCHEMBL21727957 | 0.85 | CYP1A2 (0.55) | CYP1A2MAPK1SMN1; SMN2NFKB1LMNA | |
| SCHEMBL11429662 | 0.85 | CYP1A2 (0.55) | CYP1A2MAPK1SMN1; SMN2NFKB1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0468519-B1 | Dyeable hot-bulked polypropylene fibers modified with a copolyamide | DU PONT (US) | 1996-02-14 | — | — | EP | disclosed |
| US-5130069-A | Melt extrusion, stretching | E. I. DU PONT DE NEMOURS AND COMPANY (US) | 1992-07-14 | — | — | US | disclosed |
| EP-0468519-A1 | Dyeable hot-bulked polypropylene fibers modified with a copolyamide | E.I. DU PONT DE NEMOURS AND COMPANY (US) | 1992-01-29 | — | — | EP | disclosed |