Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM1A | O60341 | 3/20 | 0.44 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.44 |
| ▸ | KDM1B | Q8NB78 | 1/20 | 0.44 |
| ▸ | RCOR1 | Q9UKL0 | 1/20 | 0.37 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.35 |
| ▸ | IDO1 | P14902 | 1/20 | 0.31 |
| ▸ | EP300 | Q09472 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8962804 | 1.00 | KDM1A (0.44) | KDM1AKCNH2KDM1BRCOR1HDAC2 | |
| SCHEMBL8962935 | 0.96 | KDM1A (0.41) | KDM1AKCNH2KDM1BRCOR1HDAC2 | |
| SCHEMBL8962923 | 0.89 | KDM1A (0.37) | KDM1AKCNH2KDM1BRCOR1HDAC2 | |
| SCHEMBL8962932 | 0.89 | KDM1A (0.37) | KDM1AKCNH2KDM1BRCOR1HDAC2 | |
| SCHEMBL8962808 | 0.86 | KDM1A (0.36) | KDM1AKCNH2HDAC2 | |
| SCHEMBL8962817 | 0.86 | KDM1A (0.36) | KDM1AKCNH2HDAC2 | |
| SCHEMBL17780006 | 0.83 | KDM1A (0.58) | KDM1AKCNH2KDM1BRCOR1IDO1 | |
| SCHEMBL8962613 | 0.83 | SLC6A2 (0.35) | KCNH2HDAC2 | |
| SCHEMBL8962617 | 0.83 | SLC6A2 (0.35) | KCNH2HDAC2 | |
| SCHEMBL8963266 | 0.82 | SLC6A3 (0.35) | HDAC2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0559860-B1 | HALOVINYL-DERIVATIVES | HOFFMANN LA ROCHE (CH) | 1996-02-14 | — | — | EP | disclosed |
| US-5364556-A | Halovinyl-derivatives | HOFFMANN-LA ROCHE INC. (US) | 1994-11-15 | — | — | US | disclosed |
| EP-0559860-A1 | HALOVINYL-DERIVATIVES. | HOFFMANN LA ROCHE (CH) | 1993-09-15 | — | — | EP | disclosed |
| WO-1993007234-A1 | HALOVINYL-DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 1993-04-15 | — | — | WO | disclosed |