Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM1A | O60341 | 3/20 | 0.37 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.37 |
| ▸ | KDM1B | Q8NB78 | 1/20 | 0.37 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.35 |
| ▸ | EP300 | Q09472 | 1/20 | 0.34 |
| ▸ | KIF11 | P52732 | 1/20 | 0.33 |
| ▸ | RCOR1 | Q9UKL0 | 1/20 | 0.32 |
| ▸ | TNKS | O95271 | 2/20 | 0.31 |
| ▸ | TNKS2 | Q9H2K2 | 2/20 | 0.31 |
| ▸ | IDO1 | P14902 | 1/20 | 0.31 |
| ▸ | NPC1 | O15118 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8962932 | 1.00 | KDM1A (0.37) | KDM1AKCNH2KDM1BHDAC2EP300 | |
| SCHEMBL8962813 | 0.89 | KDM1A (0.44) | KDM1AKCNH2KDM1BHDAC2EP300 | |
| SCHEMBL8962804 | 0.89 | KDM1A (0.44) | KDM1AKCNH2KDM1BHDAC2EP300 | |
| SCHEMBL8963237 | 0.87 | P2RY14 (0.35) | KDM1AHDAC2TNKSTNKS2NPC1 | |
| SCHEMBL8963228 | 0.87 | P2RY14 (0.35) | KDM1AHDAC2TNKSTNKS2NPC1 | |
| SCHEMBL8962842 | 0.85 | JAK2 (0.35) | KCNH2HDAC2NPC1RAB9A | |
| SCHEMBL8962836 | 0.85 | JAK2 (0.35) | KCNH2HDAC2NPC1RAB9A | |
| SCHEMBL8962935 | 0.85 | KDM1A (0.41) | KDM1AKCNH2KDM1BHDAC2RCOR1 | |
| SCHEMBL8963099 | 0.84 | HDAC2 (0.40) | KDM1AKCNH2KDM1BHDAC2RCOR1 | |
| SCHEMBL8963107 | 0.84 | HDAC2 (0.40) | KDM1AKCNH2KDM1BHDAC2RCOR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0559860-B1 | HALOVINYL-DERIVATIVES | HOFFMANN LA ROCHE (CH) | 1996-02-14 | — | — | EP | disclosed |
| US-5364556-A | Halovinyl-derivatives | HOFFMANN-LA ROCHE INC. (US) | 1994-11-15 | — | — | US | disclosed |
| EP-0559860-A1 | HALOVINYL-DERIVATIVES. | HOFFMANN LA ROCHE (CH) | 1993-09-15 | — | — | EP | disclosed |
| WO-1993007234-A1 | HALOVINYL-DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 1993-04-15 | — | — | WO | disclosed |