SCHEMBL8962891

SCHEMBL8962891

Br/C=C/[C@H]1CC[C@H](C2CCC(c3ccc(Br)cc3)CC2)CC1

nearest known ligand 0.41

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
HDAC2 Q92769 1/20 0.41
MAOB P27338 5/20 0.35
MAOA P21397 2/20 0.35
SLC18A3 Q16572 2/20 0.33
BRD4 O60885 1/20 0.33
SLC6A2 P23975 1/20 0.33
SLC6A4 P31645 1/20 0.33
SLC6A3 Q01959 1/20 0.33
ESR2 Q92731 3/20 0.33
HTR2C P28335 2/20 0.33
HTR2B P41595 2/20 0.33
ESR1 P03372 1/20 0.33
CYP3A4 P08684 1/20 0.33
CYP2C9 P11712 1/20 0.33
KDM1A O60341 5/20 0.32
KCNH2 Q12809 2/20 0.32
RCOR1 Q9UKL0 2/20 0.32
KDM1B Q8NB78 1/20 0.32
USP5 P45974 1/20 0.32

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8963290 0.85 DRD2 (0.41) HDAC2MAOBMAOASLC18A3CYP2C9
SCHEMBL8963395 0.85 HDAC2 (0.40) HDAC2MAOBMAOABRD4ESR2
SCHEMBL8962682 0.85 SLC18A3 (0.39) HDAC2MAOBMAOASLC18A3ESR2
SCHEMBL9300674 0.85 HDAC2 (0.37) HDAC2MAOBMAOASLC6A2SLC6A4
SCHEMBL28580900 0.83 KDM1A (0.43) MAOBBRD4SLC6A2SLC6A4SLC6A3
SCHEMBL8962745 0.82 SPHK1 (0.37) HDAC2MAOBMAOAESR2
SCHEMBL8453390 0.82 HDAC2 (0.36) HDAC2MAOBMAOASLC18A3
SCHEMBL8453387 0.82 HDAC2 (0.36) HDAC2MAOBMAOASLC18A3
SCHEMBL8448085 0.82 HDAC2 (0.36) HDAC2MAOBMAOASLC6A2SLC6A4
SCHEMBL8448079 0.82 HDAC2 (0.36) HDAC2MAOBMAOASLC6A2SLC6A4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0559860-B1 HALOVINYL-DERIVATIVES HOFFMANN LA ROCHE (CH) 1996-02-14 EP disclosed
US-5364556-A Halovinyl-derivatives HOFFMANN-LA ROCHE INC. (US) 1994-11-15 US disclosed
WO-1993007234-A1 HALOVINYL-DERIVATIVES F. HOFFMANN-LA ROCHE AG (CH) 1993-04-15 WO disclosed