Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 2/20 | 0.53 |
| ▸ | P2RY14 | Q15391 | 11/20 | 0.40 |
| ▸ | DRD5 | P21918 | 5/20 | 0.39 |
| ▸ | TMEM97 | Q5BJF2 | 5/20 | 0.39 |
| ▸ | SIGMAR1 | Q99720 | 5/20 | 0.39 |
| ▸ | ADRB3 | P13945 | 4/20 | 0.39 |
| ▸ | DRD1 | P21728 | 4/20 | 0.39 |
| ▸ | ADRA1B | P35368 | 4/20 | 0.39 |
| ▸ | ADRA2B | P18089 | 3/20 | 0.39 |
| ▸ | HTR1A | P08908 | 2/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.39 |
| ▸ | AGTR1 | P30556 | 2/20 | 0.39 |
| ▸ | DRD3 | P35462 | 2/20 | 0.39 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.39 |
| ▸ | ADRA2A | P08913 | 2/20 | 0.39 |
| ▸ | PDE2A | O00408 | 1/20 | 0.39 |
| ▸ | PDE5A | O76074 | 1/20 | 0.39 |
| ▸ | EGFR | P00533 | 1/20 | 0.39 |
| ▸ | INSR | P06213 | 1/20 | 0.39 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8962904 | 1.00 | HTR2C (0.53) | HTR2CP2RY14DRD5TMEM97SIGMAR1 | |
| SCHEMBL8963017 | 0.95 | HTR2C (0.57) | HTR2CMAOB | |
| SCHEMBL8963025 | 0.95 | HTR2C (0.57) | HTR2CMAOB | |
| SCHEMBL8962960 | 0.91 | HTR2C (0.53) | HTR2CP2RY14MAOB | |
| SCHEMBL8962970 | 0.88 | HTR2C (0.50) | HTR2CCHRM2CHRM5MAOBDGAT1 | |
| SCHEMBL8962978 | 0.88 | HTR2C (0.50) | HTR2CCHRM2CHRM5MAOBDGAT1 | |
| SCHEMBL9450845 | 0.85 | HTR2C (0.47) | HTR2CCHRM2CHRM5MAOBDGAT1 | |
| SCHEMBL8963014 | 0.82 | HDAC2 (0.45) | HTR2CSIGMAR1MAOB | |
| SCHEMBL8963019 | 0.82 | HDAC2 (0.45) | HTR2CSIGMAR1MAOB | |
| SCHEMBL8962715 | 0.81 | L3MBTL1 (0.41) | P2RY14KIF11KDM1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0559860-B1 | HALOVINYL-DERIVATIVES | HOFFMANN LA ROCHE (CH) | 1996-02-14 | — | — | EP | disclosed |
| US-5364556-A | Halovinyl-derivatives | HOFFMANN-LA ROCHE INC. (US) | 1994-11-15 | — | — | US | disclosed |