Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE2A | O00408 | 3/20 | 0.35 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.35 |
| ▸ | MGLL | Q99685 | 2/20 | 0.33 |
| ▸ | KDM1A | O60341 | 2/20 | 0.31 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.30 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.30 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8963217 | 1.00 | PDE2A (0.35) | PDE2APDE10AMGLLKDM1ATLR9 | |
| SCHEMBL8962853 | 0.96 | PDE2A (0.36) | PDE2APDE10AMGLL | |
| SCHEMBL8963112 | 0.90 | JAK2 (0.34) | PDE2APDE10A | |
| SCHEMBL8963104 | 0.90 | JAK2 (0.34) | PDE2APDE10A | |
| SCHEMBL8454674 | 0.82 | MGLL (0.33) | PDE2APDE10AMGLL | |
| SCHEMBL8454678 | 0.82 | MGLL (0.33) | PDE2APDE10AMGLL | |
| SCHEMBL8963018 | 0.82 | EPHX2 (0.36) | PDE2AKDM1A | |
| SCHEMBL8963026 | 0.82 | EPHX2 (0.36) | PDE2AKDM1A | |
| SCHEMBL8963152 | 0.81 | PDE2A (0.31) | PDE2APDE10A | |
| SCHEMBL8448650 | 0.81 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0559860-B1 | HALOVINYL-DERIVATIVES | HOFFMANN LA ROCHE (CH) | 1996-02-14 | — | — | EP | disclosed |
| US-5364556-A | Halovinyl-derivatives | HOFFMANN-LA ROCHE INC. (US) | 1994-11-15 | — | — | US | disclosed |
| EP-0559860-A1 | HALOVINYL-DERIVATIVES. | HOFFMANN LA ROCHE (CH) | 1993-09-15 | — | — | EP | disclosed |
| WO-1993007234-A1 | HALOVINYL-DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 1993-04-15 | — | — | WO | disclosed |