Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 3/20 | 0.37 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.34 |
| ▸ | MTOR | P42345 | 2/20 | 0.34 |
| ▸ | IDO1 | P14902 | 1/20 | 0.33 |
| ▸ | NPC1 | O15118 | 2/20 | 0.33 |
| ▸ | RAB9A | P51151 | 2/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.33 |
| ▸ | NOTUM | Q6P988 | 2/20 | 0.33 |
| ▸ | CSF1R | P07333 | 2/20 | 0.32 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.32 |
| ▸ | F2R | P25116 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8963379 | 1.00 | PDE10A (0.37) | PDE10AL3MBTL1KDM4EHRH3MTOR | |
| SCHEMBL9542379 | 0.93 | PDE10A (0.39) | PDE10AL3MBTL1KDM4EHRH3MTOR | |
| SCHEMBL8962748 | 0.89 | SMN1; SMN2 (0.35) | L3MBTL1KDM4EMTORIDO1NPC1 | |
| SCHEMBL8962756 | 0.89 | SMN1; SMN2 (0.35) | L3MBTL1KDM4EMTORIDO1NPC1 | |
| SCHEMBL8963105 | 0.86 | RAB9A (0.41) | L3MBTL1KDM4EIDO1NPC1RAB9A | |
| SCHEMBL8963100 | 0.86 | RAB9A (0.41) | L3MBTL1KDM4EIDO1NPC1RAB9A | |
| SCHEMBL12151773 | 0.86 | PDE10A (0.43) | PDE10AL3MBTL1KDM4EHRH3MTOR | |
| SCHEMBL8963199 | 0.85 | CSF1R (0.38) | PDE10AL3MBTL1IDO1CSF1RMEN1 | |
| SCHEMBL8963194 | 0.85 | CSF1R (0.38) | PDE10AL3MBTL1IDO1CSF1RMEN1 | |
| SCHEMBL8963136 | 0.85 | RAB9A (0.41) | L3MBTL1KDM4ENPC1RAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0559860-B1 | HALOVINYL-DERIVATIVES | HOFFMANN LA ROCHE (CH) | 1996-02-14 | — | — | EP | disclosed |
| US-5364556-A | Halovinyl-derivatives | HOFFMANN-LA ROCHE INC. (US) | 1994-11-15 | — | — | US | disclosed |