SCHEMBL896413

SCHEMBL896413

COc1cc(C[C@@H]2SC(=O)NC2=O)ccc1C(=O)NCc1ccc(C(F)(F)F)cc1

nearest known ligand 0.52

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
PPARG P37231 7/20 0.52
PPARA Q07869 14/20 0.51
PTPN1 P18031 2/20 0.51
PPARD Q03181 5/20 0.49
PSEN1 P49768 3/20 0.48
PSEN2 P49810 3/20 0.48
APH1B Q8WW43 3/20 0.48
NCSTN Q92542 3/20 0.48
APH1A Q96BI3 3/20 0.48
PSENEN Q9NZ42 3/20 0.48
FFAR1 O14842 1/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20125593 0.93 PPARA (0.61) PPARGPPARAPTPN1PPARDPSEN1
SCHEMBL3922 0.93 PPARA (0.61) PPARGPPARAPTPN1PPARDPSEN1
SCHEMBL29358494 0.93 PPARA (0.61) PPARGPPARAPTPN1PPARDPSEN1
SCHEMBL14379043 0.93 PPARA (0.61) PPARGPPARAPTPN1PPARDPSEN1
SCHEMBL7454210 0.85 PPARG (0.56) PPARGPPARAPPARDPSEN1PSEN2
SCHEMBL7465714 0.85 PPARG (0.50) PPARGPPARAPPARDPSEN1PSEN2
SCHEMBL6502439 0.85 PPARD (0.61) PPARGPPARAPTPN1PPARD
SCHEMBL7462895 0.84 PPARA (0.52) PPARGPPARAPTPN1PPARDPSEN1
SCHEMBL3974261 0.84 PPARG (0.55) PPARGPPARAPPARDPSEN1PSEN2
SCHEMBL6506168 0.84 PPARD (0.61) PPARGPPARAPTPN1PPARD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-8793078-B2 Method for predicting activation energy using atomic fingerprint descriptor or atomic descriptor BIOINFORMATICS & MOLECULAR DESIGN RESEARCH CENTER (KR) 2014-07-29 US disclosed
US-20120084012-A1 METHOD FOR PREDICTING ACTIVATION ENERGY USING ATOMIC FINGERPRINT DESCRIPTOR OR ATOMIC DESCRIPTOR BIOINFORMATICS & MOLECULAR DESIGN RESEARCH CENTER (KR) 2012-04-05 US disclosed
US-20110213558-A1 METHOD FOR PREDICTING ACTIVATION ENERGY USING AN ATOMIC FINGERPRINT DESCRIPTOR OR AN ATOMIC DESCRIPTOR BIOINFORMATICS & MOLECULAR DESIGN RESEARCH CENTER (KR) 2011-09-01 US disclosed
EP-2354987-A2 METHOD FOR PREDICTING ACTIVATION ENERGY USING AN ATOMIC FINGERPRINT DESCRIPTOR OR AN ATOMIC DESCRIPTOR Bioinformatics&Molecular Design Research Center (KR) 2011-08-10 EP disclosed
WO-2010056053-A2 METHOD FOR PREDICTING ACTIVATION ENERGY USING AN ATOMIC FINGERPRINT DESCRIPTOR OR AN ATOMIC DESCRIPTOR 사단법인 분자설계연구소 (KR) 2010-05-20 WO disclosed