SCHEMBL3974261

SCHEMBL3974261

O=C1NC(=O)C(Cc2ccc(O)c(C(=O)NCc3ccc(C(F)(F)F)cc3)c2)S1

nearest known ligand 0.55

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
PPARG P37231 2/20 0.55
P2RX1 P51575 1/20 0.47
TMPRSS4 Q9NRS4 1/20 0.47
FFAR1 O14842 3/20 0.47
KDM1A O60341 1/20 0.45
HDAC1 Q13547 1/20 0.45
PPARA Q07869 8/20 0.42
ALDH1A1 P00352 1/20 0.42
NPSR1 Q6W5P4 1/20 0.42
SORT1 Q99523 1/20 0.42
MAPT P10636 1/20 0.42
PPARD Q03181 1/20 0.41
MTOR P42345 1/20 0.41
MAOA P21397 1/20 0.40
MAOB P27338 1/20 0.40
CISD1 Q9NZ45 1/20 0.40
PSEN1 P49768 1/20 0.40
PSEN2 P49810 1/20 0.40
APH1B Q8WW43 1/20 0.40
NCSTN Q92542 1/20 0.40

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7454210 0.91 PPARG (0.56) PPARGFFAR1PPARAALDH1A1NPSR1
SCHEMBL13451554 0.89 PPARG (0.54) PPARGFFAR1PPARAALDH1A1NPSR1
SCHEMBL3922 0.86 PPARA (0.61) PPARGPPARAPPARDPSEN1PSEN2
SCHEMBL29358494 0.86 PPARA (0.61) PPARGPPARAPPARDPSEN1PSEN2
SCHEMBL20125593 0.86 PPARA (0.61) PPARGPPARAPPARDPSEN1PSEN2
SCHEMBL14379043 0.86 PPARA (0.61) PPARGPPARAPPARDPSEN1PSEN2
SCHEMBL7465714 0.85 PPARG (0.50) PPARGFFAR1PPARAPPARDPSEN1
SCHEMBL896413 0.84 PPARG (0.52) PPARGFFAR1PPARAPPARDPSEN1
SCHEMBL7462895 0.84 PPARA (0.52) PPARGFFAR1PPARAPPARDPSEN1
SCHEMBL6239522 0.78 PPARA (0.59) PPARGFFAR1PPARAPPARDPSEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2009043593-A1 COMBINATION THERAPY USING MEMANTINE AND GLITAZONES MERZ PHARMA GMBH & CO. KGAA (DE) 2009-04-09 WO disclosed
EP-0846693-B1 N-BENZYLDIOXOTHIAZOLIDYLBENZAMIDE DERIVATIVES AND PROCESS FOR PRODUCING THE SAME KYORIN SEIYAKU KK (JP) 2002-01-23 EP disclosed
CN-1069901-C N-benzyldioxothiazolidylbenzamide derivatives and process for producing the same KYORIN SEIYAKU KK (JP) 2001-08-22 CN disclosed
US-6147101-A TREATING HYPERGLYCEMIA KYORIN PHARMACEUTICAL CO., LTD. (JP) 2000-11-14 US disclosed
US-6030990-A ANTIDIABETIC AND -LIPEMIC AGENTS; PARTICULARLY FOR NON-INSULIN DEPENDENT DIABETES MELLITUS, A BLOOD SUGAR-LOWERING DRUG THAT IMPROVES THE INSULIN RESISTANCE AND HAS HIGH SAFETY AND EFFICIENCY KYORIN PHARMACEUTICAL CO., LTD. (JP) 2000-02-29 US disclosed
US-6001862-A ADMINISTERING TO A PATIENT SUFFERING FROM NON-INSULIN DEPENDENT DIABETES MELLITUS A N-BENZYLDIOXOTHIAZOLIDYLBENZAMIDE COMPOUND KYORIN PHARAMEUTICALS CO., LTD. (JP) 1999-12-14 US disclosed
CN-1186489-A N-benzyldioxothiazolidylbenzamide derivatives and process for producing the same KYORIN SEIYAKU KK (JP) 1998-07-01 CN disclosed
EP-0846693-A1 N-BENZYLDIOXOTHIAZOLIDYLBENZAMIDE DERIVATIVES AND PROCESS FOR PRODUCING THE SAME KYORIN PHARMACEUTICAL CO., LTD. (JP) 1998-06-10 EP disclosed