Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 1/20 | 0.56 |
| ▸ | RAB9A | P51151 | 1/20 | 0.56 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.56 |
| ▸ | MAOB | P27338 | 10/20 | 0.54 |
| ▸ | BCHE | P06276 | 2/20 | 0.52 |
| ▸ | APP | P05067 | 1/20 | 0.50 |
| ▸ | TLR4 | O00206 | 1/20 | 0.48 |
| ▸ | TLR2 | O60603 | 1/20 | 0.48 |
| ▸ | SMPD1 | P17405 | 1/20 | 0.48 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8964634 | 0.86 | APP (0.56) | NPC1RAB9ATDP1MAOBAPP | |
| SCHEMBL28567450 | 0.82 | ALDH1A1 (0.60) | NPC1RAB9ATDP1MAOBBCHE | |
| SCHEMBL13462938 | 0.78 | MAOB (0.65) | NPC1RAB9ATDP1MAOBBCHE | |
| SCHEMBL10820376 | 0.78 | MAOB (0.67) | NPC1RAB9ATDP1MAOBBCHE | |
| SCHEMBL7813380 | 0.77 | MAOB (0.63) | NPC1RAB9ATDP1MAOBBCHE | |
| SCHEMBL8965482 | 0.75 | IDO1 (0.44) | NPC1RAB9ATDP1MAOBBCHE | |
| SCHEMBL8964668 | 0.75 | IDO1 (0.44) | NPC1RAB9ATDP1MAOBAPP | |
| SCHEMBL28084246 | 0.75 | IDO1 (0.56) | MAOB | |
| SCHEMBL24041859 | 0.74 | CYP4F2 (0.74) | NPC1RAB9ATDP1MAOBBCHE | |
| SCHEMBL10819608 | 0.74 | NPC1 (0.61) | NPC1RAB9ATDP1MAOBBCHE |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0410379-B1 | Pharmaceutically active 3-aryl and 3-heteroaryl-2-fluoro-1-olefins | MERRELL DOW PHARMA (US) | 1996-01-31 | — | — | EP | disclosed |
| US-5068465-A | Hypotensive agents or enzyme inhibitors for treatment of hypertension | MERRELL DOW PHARMACEUTICALS INC. (US) | 1991-11-26 | — | — | US | disclosed |
| EP-0410379-A2 | Pharmaceutically active 3-aryl and 3-heteroaryl-2-fluoro-1-olefins | MERRELL DOW PHARMACEUTICALS INC. (US) | 1991-01-30 | — | — | EP | disclosed |
| US-4981868-A | ENZYME INHIBITORS, HYPOTENSIVES | MERRELL DOW PHARMACEUTICAL (US) | 1991-01-01 | — | — | US | disclosed |