Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NFE2L2 | Q16236 | 8/20 | 0.46 |
| ▸ | RELA | Q04206 | 4/20 | 0.42 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.41 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.41 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.41 |
| ▸ | NQO2 | P16083 | 1/20 | 0.41 |
| ▸ | KDM1A | O60341 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.40 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.40 |
| ▸ | MMP1 | P03956 | 1/20 | 0.40 |
| ▸ | MMP2 | P08253 | 1/20 | 0.40 |
| ▸ | MMP3 | P08254 | 1/20 | 0.40 |
| ▸ | MMP7 | P09237 | 1/20 | 0.40 |
| ▸ | MMP9 | P14780 | 1/20 | 0.40 |
| ▸ | MMP8 | P22894 | 1/20 | 0.40 |
| ▸ | MMP13 | P45452 | 1/20 | 0.40 |
| ▸ | MMP14 | P50281 | 1/20 | 0.40 |
| ▸ | FBP1 | P09467 | 1/20 | 0.40 |
| ▸ | TRPM2 | O94759 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8965132 | 0.90 | BCL2L1 (0.48) | NFE2L2RELAPTGS2ESR2KDM1A | |
| SCHEMBL8965558 | 0.90 | BCL2L1 (0.48) | NFE2L2RELAPTGS2ESR2KDM1A | |
| SCHEMBL8965561 | 0.90 | BCL2L1 (0.48) | NFE2L2RELAPTGS2ESR2KDM1A | |
| SCHEMBL9063419 | 0.81 | HDAC2 (0.43) | RELAPTGS2MMP1MMP2MMP3 | |
| SCHEMBL9063905 | 0.81 | HDAC2 (0.43) | RELAPTGS2MMP1MMP2MMP3 | |
| SCHEMBL8965195 | 0.78 | RELA (0.49) | NFE2L2RELANQO2HDAC1HDAC6 | |
| SCHEMBL8964911 | 0.78 | CYP17A1 (0.48) | NFE2L2RELAPTGS1PTGS2NQO2 | |
| SCHEMBL8964908 | 0.78 | CYP17A1 (0.48) | NFE2L2RELAPTGS1PTGS2NQO2 | |
| SCHEMBL8964910 | 0.78 | CYP17A1 (0.48) | NFE2L2RELAPTGS1PTGS2NQO2 | |
| SCHEMBL8964905 | 0.78 | CYP17A1 (0.48) | NFE2L2RELAPTGS1PTGS2NQO2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0696271-A1 | CYCLOOXYGENASE AND 5-LIPOXYGENASE INHIBITING HYDROXAMIC ACID DERIVATIVES | THE WELLCOME FOUNDATION LIMITED (GB) | 1996-02-14 | — | — | EP | disclosed |
| WO-1994025430-A1 | CYCLOOXYGENASE AND 5-LIPOXYGENASE INHIBITING HYDROXAMIC ACID DERIVATIVES | THE WELLCOME FOUNDATION LIMITED (GB) | 1994-11-10 | — | — | WO | disclosed |