Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP17A1 | P05093 | 5/20 | 0.48 |
| ▸ | CYP21A2 | P08686 | 5/20 | 0.48 |
| ▸ | CYP11B1 | P15538 | 4/20 | 0.48 |
| ▸ | PTGS1 | P23219 | 3/20 | 0.37 |
| ▸ | PTGS2 | P35354 | 2/20 | 0.37 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.37 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.37 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | MMP1 | P03956 | 1/20 | 0.35 |
| ▸ | MMP2 | P08253 | 1/20 | 0.35 |
| ▸ | MMP3 | P08254 | 1/20 | 0.35 |
| ▸ | MMP7 | P09237 | 1/20 | 0.35 |
| ▸ | MMP9 | P14780 | 1/20 | 0.35 |
| ▸ | MMP8 | P22894 | 1/20 | 0.35 |
| ▸ | MMP13 | P45452 | 1/20 | 0.35 |
| ▸ | MMP14 | P50281 | 1/20 | 0.35 |
| ▸ | AKR1C4 | P17516 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8964908 | 1.00 | CYP17A1 (0.48) | CYP17A1CYP21A2CYP11B1PTGS1PTGS2 | |
| SCHEMBL8964905 | 1.00 | CYP17A1 (0.48) | CYP17A1CYP21A2CYP11B1PTGS1PTGS2 | |
| SCHEMBL8964911 | 1.00 | CYP17A1 (0.48) | CYP17A1CYP21A2CYP11B1PTGS1PTGS2 | |
| SCHEMBL8965087 | 0.88 | MEN1 (0.44) | PTGS1PTGS2ALOX5NFE2L2MEN1 | |
| SCHEMBL8965558 | 0.85 | BCL2L1 (0.48) | CYP17A1PTGS2ALOX5NFE2L2CYP3A4 | |
| SCHEMBL8965132 | 0.85 | BCL2L1 (0.48) | CYP17A1PTGS2ALOX5NFE2L2CYP3A4 | |
| SCHEMBL8965561 | 0.85 | BCL2L1 (0.48) | CYP17A1PTGS2ALOX5NFE2L2CYP3A4 | |
| SCHEMBL8965199 | 0.78 | NFE2L2 (0.46) | PTGS1PTGS2NFE2L2MMP1MMP2 | |
| SCHEMBL8965093 | 0.74 | ALOX5 (0.46) | CYP17A1CYP21A2CYP11B1ALOX5CYP3A4 | |
| SCHEMBL8965175 | 0.74 | ALOX5 (0.46) | CYP17A1CYP21A2CYP11B1ALOX5CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0696271-A1 | CYCLOOXYGENASE AND 5-LIPOXYGENASE INHIBITING HYDROXAMIC ACID DERIVATIVES | THE WELLCOME FOUNDATION LIMITED (GB) | 1996-02-14 | — | — | EP | disclosed |
| WO-1994025430-A1 | CYCLOOXYGENASE AND 5-LIPOXYGENASE INHIBITING HYDROXAMIC ACID DERIVATIVES | THE WELLCOME FOUNDATION LIMITED (GB) | 1994-11-10 | — | — | WO | disclosed |