Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.59 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.59 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.58 |
| ▸ | ALDH3A1 | P30838 | 1/20 | 0.52 |
| ▸ | MEN1 | O00255 | 3/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.49 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.49 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 2/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | GAA | P10253 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.49 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.49 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.49 |
| ▸ | PRKCQ | Q04759 | 4/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8966415 | 0.86 | MAPT (0.55) | MAPTMAPK1L3MBTL1ALDH1A1ALDH3A1 | |
| SCHEMBL20129837 | 0.82 | HTR6 (0.60) | MAPTALDH1A1ALDH3A1MEN1KMT2A | |
| SCHEMBL8966029 | 0.80 | MAPT (0.47) | MAPTL3MBTL1ALDH1A1ALDH3A1MEN1 | |
| SCHEMBL6151067 | 0.75 | MAPT (0.50) | MAPTMAPK1L3MBTL1ALDH1A1ALDH3A1 | |
| SCHEMBL7328985 | 0.75 | MAPT (1.00) | MAPTMAPK1L3MBTL1ALDH1A1MEN1 | |
| SCHEMBL10385970 | 0.74 | MAPT (0.59) | MAPTALDH1A1MEN1KMT2ARAB9A | |
| SCHEMBL20129851 | 0.74 | TSHR (0.59) | MAPTMAPK1L3MBTL1ALDH1A1MEN1 | |
| SCHEMBL2236853 | 0.74 | HTT (0.49) | MAPTL3MBTL1ALDH1A1MEN1KMT2A | |
| SCHEMBL5955396 | 0.74 | NR4A2 (0.47) | MAPTMAPK1L3MBTL1ALDH1A1MEN1 | |
| SCHEMBL17749098 | 0.74 | PKM (0.53) | MAPTL3MBTL1ALDH1A1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0554543-B1 | 1,2,4-Triaminobenzene derivatives and process for their preparation | ASTA MEDICA AG (DE) | 1996-02-28 | — | — | EP | disclosed |
| US-5384330-A | Pharmaceutically active 1,2,4-triamino-benzene derivatives, processes for their preparation and pharmaceutical compositions containing them | ASTA MEDICA AKTIENGESELLSCHAFT (DE) | 1995-01-24 | — | — | US | disclosed |
| EP-0554543-A2 | 1,2,4-Triaminobenzene derivatives and process for their preparation | ASTA Medica Aktiengesellschaft (DE) | 1993-08-11 | — | — | EP | disclosed |