Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 5/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | MBTD1 | Q05BQ5 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.40 |
| ▸ | HRH1 | P35367 | 1/20 | 0.40 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27342847 | 0.88 | HRH3 (0.65) | HRH3SMN1; SMN2CYP1A2MAPK1KCNH2 | |
| SCHEMBL8967602 | 0.85 | SMN1; SMN2 (0.43) | HRH3SMN1; SMN2CYP1A2MAPK1MBTD1 | |
| SCHEMBL25926402 | 0.82 | CA2 (0.42) | HRH3SMN1; SMN2CYP1A2MAPK1 | |
| SCHEMBL8966731 | 0.81 | CA2 (0.41) | HRH3SMN1; SMN2CYP1A2MAPK1L3MBTL1 | |
| SCHEMBL8966787 | 0.79 | CA2 (0.44) | HRH3ALDH1A1 | |
| SCHEMBL27431610 | 0.79 | SIGMAR1 (0.44) | HRH3 | |
| SCHEMBL8967588 | 0.79 | CA2 (0.44) | HRH3ALDH1A1 | |
| SCHEMBL8967439 | 0.79 | HRH3 (0.48) | HRH3SMN1; SMN2CYP1A2MAPK1KCNH2 | |
| SCHEMBL8967504 | 0.78 | HRH3 (0.41) | HRH3SMN1; SMN2CYP1A2MAPK1L3MBTL1 | |
| SCHEMBL31457403 | 0.78 | PAOX (0.44) | SMN1; SMN2ALDH1A1TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0468434-B1 | Novel piperidyl ethers and thioethers as inhibitors of cholesterol biosynthesis | MERRELL DOW PHARMA (US) | 1996-02-28 | — | — | EP | disclosed |
| US-5348964-A | Anticholesterol agents or fungicides | MERRELL DOW PHARMACEUTICALS INC. (US) | 1994-09-20 | — | — | US | disclosed |
| CN-1058399-A | New piperidine ether and thioether as cholesteral biosynthesis inhibitor | MERRELL DOW PHARMA (US) | 1992-02-05 | — | — | CN | disclosed |
| EP-0468434-A1 | Novel piperidyl ethers and thioethers as inhibitors of cholesterol biosynthesis | MERRELL PHARMACEUTICALS INC. (US) | 1992-01-29 | — | — | EP | disclosed |