Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 8/20 | 0.62 |
| ▸ | BCHE | P06276 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | LMNA | P02545 | 2/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | CTSD | P07339 | 4/20 | 0.36 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.35 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.35 |
| ▸ | HRH4 | Q9H3N8 | 2/20 | 0.35 |
| ▸ | DRD2 | P14416 | 2/20 | 0.34 |
| ▸ | DRD4 | P21917 | 2/20 | 0.34 |
| ▸ | DRD3 | P35462 | 2/20 | 0.34 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.33 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.33 |
| ▸ | HTR3B | O95264 | 1/20 | 0.33 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8969674 | 0.81 | ACHE (0.50) | ACHEMEN1LMNACYP3A4KMT2A | |
| SCHEMBL8969387 | 0.80 | ACHE (0.62) | ACHEBCHEMEN1LMNACYP3A4 | |
| SCHEMBL8969669 | 0.80 | ACHE (0.40) | ACHECHRM4 | |
| SCHEMBL8969190 | 0.79 | ACHE (0.89) | ACHEBCHEMEN1LMNACYP3A4 | |
| SCHEMBL8968773 | 0.78 | ACHE (0.97) | ACHEBCHEMEN1LMNACYP3A4 | |
| SCHEMBL8968453 | 0.77 | ACHE (1.00) | ACHEBCHEMEN1LMNACYP3A4 | |
| SCHEMBL8968451 | 0.74 | ACHE (0.62) | ACHEBCHEMEN1LMNACYP3A4 | |
| SCHEMBL24330116 | 0.72 | ACHE (0.67) | ACHELMNAALDH1A1HRH4DRD2 | |
| SCHEMBL8969066 | 0.69 | ACHE (0.67) | ACHEBCHEMEN1LMNACYP3A4 | |
| SCHEMBL8969701 | 0.69 | ACHE (0.58) | ACHEBCHEMEN1LMNACYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5486512-A | LEARNING ENHANCEMENT | WARNER-LAMBERT COMPANY (US) | 1996-01-23 | — | — | US | disclosed |
| EP-0597956-A1 | QUINAZOLINE DERIVATIVES AS ACETYLCHOLINESTERASE INHIBITORS | WARNER-LAMBERT COMPANY (US) | 1994-05-25 | — | — | EP | disclosed |
| WO-1993003034-A1 | QUINAZOLINE DERIVATIVES AS ACETYLCHOLINESTERASE INHIBITORS | WARNER-LAMBERT COMPANY (US) | 1993-02-18 | — | — | WO | disclosed |