Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 13/20 | 0.57 |
| ▸ | BCHE | P06276 | 2/20 | 0.47 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | LMNA | P02545 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | USP2 | O75604 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | CHKA | P35790 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.40 |
| ▸ | MAOB | P27338 | 2/20 | 0.40 |
| ▸ | MAOA | P21397 | 1/20 | 0.40 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8969588 | 0.99 | ACHE (0.55) | ACHEBCHEHRH3ALDH1A1LMNA | |
| SCHEMBL8968388 | 0.81 | ACHE (0.61) | ACHEBCHEHRH3ALDH1A1LMNA | |
| SCHEMBL8969616 | 0.79 | ACHE (0.58) | ACHEBCHEHRH3ALDH1A1LMNA | |
| SCHEMBL8968730 | 0.79 | ACHE (0.63) | ACHEBCHEHRH3ALDH1A1LMNA | |
| SCHEMBL8969778 | 0.79 | ACHE (0.63) | ACHEBCHEHRH3ALDH1A1LMNA | |
| SCHEMBL8969028 | 0.78 | ACHE (0.69) | ACHEBCHEHRH3ALDH1A1LMNA | |
| SCHEMBL8968295 | 0.77 | ACHE (0.47) | ACHEBCHEHRH3ALDH1A1LMNA | |
| SCHEMBL8970082 | 0.77 | ACHE (0.50) | ACHEBCHEHRH3ALDH1A1LMNA | |
| SCHEMBL8968235 | 0.77 | ACHE (0.50) | ACHEBCHEHRH3ALDH1A1LMNA | |
| SCHEMBL8969676 | 0.77 | ACHE (0.50) | ACHEBCHEHRH3ALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5486512-A | LEARNING ENHANCEMENT | WARNER-LAMBERT COMPANY (US) | 1996-01-23 | — | — | US | disclosed |
| EP-0597956-A1 | QUINAZOLINE DERIVATIVES AS ACETYLCHOLINESTERASE INHIBITORS | WARNER-LAMBERT COMPANY (US) | 1994-05-25 | — | — | EP | disclosed |
| WO-1993003034-A1 | QUINAZOLINE DERIVATIVES AS ACETYLCHOLINESTERASE INHIBITORS | WARNER-LAMBERT COMPANY (US) | 1993-02-18 | — | — | WO | disclosed |