Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 15/20 | 0.52 |
| ▸ | KLK7 | P49862 | 1/20 | 0.35 |
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.35 |
| ▸ | CACNA2D2 | Q9NY47 | 1/20 | 0.35 |
| ▸ | BCHE | P06276 | 1/20 | 0.35 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8969937 | 0.81 | ACHE (0.52) | ACHECACNA2D1CACNA2D2BCHEHRH3 | |
| SCHEMBL8969628 | 0.79 | ACHE (0.66) | ACHEKLK7BCHEHRH3MEN1 | |
| SCHEMBL8968368 | 0.78 | ACHE (0.63) | ACHEKLK7BCHEHRH3MEN1 | |
| SCHEMBL8970569 | 0.76 | ACHE (0.44) | ACHECACNA2D1CACNA2D2S1PR1 | |
| SCHEMBL8968587 | 0.74 | ACHE (0.57) | ACHEKLK7BCHEHRH3MEN1 | |
| SCHEMBL8968295 | 0.70 | ACHE (0.47) | ACHEBCHEHRH3MEN1USP2 | |
| SCHEMBL8970082 | 0.70 | ACHE (0.50) | ACHEBCHEHRH3MEN1USP2 | |
| SCHEMBL8969676 | 0.70 | ACHE (0.50) | ACHEBCHEHRH3MEN1USP2 | |
| SCHEMBL8969785 | 0.69 | ACHE (0.63) | ACHEKLK7BCHEHRH3MEN1 | |
| SCHEMBL8969868 | 0.69 | ACHE (0.59) | ACHEKLK7BCHEHRH3MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5486512-A | LEARNING ENHANCEMENT | WARNER-LAMBERT COMPANY (US) | 1996-01-23 | — | — | US | disclosed |
| EP-0597956-A1 | QUINAZOLINE DERIVATIVES AS ACETYLCHOLINESTERASE INHIBITORS | WARNER-LAMBERT COMPANY (US) | 1994-05-25 | — | — | EP | disclosed |
| WO-1993003034-A1 | QUINAZOLINE DERIVATIVES AS ACETYLCHOLINESTERASE INHIBITORS | WARNER-LAMBERT COMPANY (US) | 1993-02-18 | — | — | WO | disclosed |