Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE | P22303 | 9/20 | 0.60 |
| ▸ | BCHE | P06276 | 4/20 | 0.60 |
| ▸ | MEN1 | O00255 | 2/20 | 0.58 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.58 |
| ▸ | USP2 | O75604 | 1/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.58 |
| ▸ | LMNA | P02545 | 1/20 | 0.58 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.58 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.40 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.40 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.39 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.39 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.39 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.39 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.39 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.39 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8969927 | 0.87 | ACHE (0.54) | ACHEBCHEMEN1KMT2AUSP2 | |
| SCHEMBL8969701 | 0.85 | ACHE (0.58) | ACHEBCHEMEN1KMT2AUSP2 | |
| SCHEMBL8969091 | 0.81 | ACHE (0.60) | ACHEBCHEMEN1KMT2AUSP2 | |
| SCHEMBL8969711 | 0.77 | ACHE (0.43) | ACHEBCHEMEN1KMT2AUSP2 | |
| SCHEMBL29416837 | 0.76 | ACHE (1.00) | ACHEBCHEMEN1KMT2AUSP2 | |
| SCHEMBL3387188 | 0.76 | ACHE (1.00) | ACHEBCHEMEN1KMT2AUSP2 | |
| SCHEMBL8968969 | 0.75 | ACHE (0.49) | ACHEBCHEMEN1KMT2AUSP2 | |
| Hydrochloric Acid SCHEMBL30600296 | 0.74 | MEN1 (1.00) | ACHEBCHEMEN1KMT2AUSP2 | |
| SCHEMBL9540233 | 0.73 | ACHE (1.00) | ACHEBCHEMEN1KMT2AUSP2 | |
| SCHEMBL8968349 | 0.73 | ACHE (0.53) | ACHEBCHEMEN1KMT2AUSP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5486512-A | LEARNING ENHANCEMENT | WARNER-LAMBERT COMPANY (US) | 1996-01-23 | — | — | US | disclosed |
| EP-0597956-A1 | QUINAZOLINE DERIVATIVES AS ACETYLCHOLINESTERASE INHIBITORS | WARNER-LAMBERT COMPANY (US) | 1994-05-25 | — | — | EP | disclosed |
| WO-1993003034-A1 | QUINAZOLINE DERIVATIVES AS ACETYLCHOLINESTERASE INHIBITORS | WARNER-LAMBERT COMPANY (US) | 1993-02-18 | — | — | WO | disclosed |