Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.46 |
| ▸ | RAB9A | P51151 | 5/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.46 |
| ▸ | THRB | P10828 | 2/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.43 |
| ▸ | NPC1 | O15118 | 4/20 | 0.43 |
| ▸ | TP53 | P04637 | 2/20 | 0.43 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.43 |
| ▸ | ACACB | O00763 | 2/20 | 0.42 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.42 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.42 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.42 |
| ▸ | PI4KA | P42356 | 1/20 | 0.42 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.42 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | CASP3 | P42574 | 1/20 | 0.39 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.39 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20784571 | 0.91 | MAPT (0.49) | MAPTRAB9AL3MBTL1THRBSMN1; SMN2 | |
| SCHEMBL8968866 | 0.83 | ACACB (0.62) | ACACB | |
| SCHEMBL9751879 | 0.82 | ACACB (0.40) | MAPTRAB9AL3MBTL1THRBSMN1; SMN2 | |
| SCHEMBL9157060 | 0.81 | SMN1; SMN2 (0.41) | MAPTRAB9AL3MBTL1THRBSMN1; SMN2 | |
| SCHEMBL5530443 | 0.81 | RAB9A (0.53) | MAPTRAB9AL3MBTL1SMN1; SMN2NPC1 | |
| SCHEMBL8969725 | 0.81 | MAPT (0.54) | MAPTRAB9AL3MBTL1SMN1; SMN2NPC1 | |
| SCHEMBL10462424 | 0.78 | MAPT (0.55) | MAPTRAB9AL3MBTL1THRBSMN1; SMN2 | |
| SCHEMBL14466730 | 0.78 | MKNK1 (0.51) | NPC1CYP19A1PKM | |
| SCHEMBL8969929 | 0.78 | ACACB (0.66) | ACACB | |
| SCHEMBL18397128 | 0.77 | MAPT (0.46) | MAPTRAB9AL3MBTL1SMN1; SMN2NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0445257-B1 | PYRIDINE DERIVATIVES AND A LIQUID CRYSTAL MEDIUM | MERCK PATENT GMBH (DE) | 1996-03-13 | — | — | EP | disclosed |
| US-5204477-A | PYRIDINE DERIVATIVES IN LIQUID CRYSTALLINE MEDIUM USEFUL FOR ELECTROOPTICAL DISPLAY ELEMENTS | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1993-04-20 | — | — | US | disclosed |
| EP-0445257-A1 | PYRIDINE DERIVATIVES AND A LIQUID CRYSTAL MEDIUM. | MERCK PATENT GMBH (DE) | 1991-09-11 | — | — | EP | disclosed |
| WO-1991004249-A1 | PYRIDINE DERIVATIVES AND A LIQUID CRYSTAL MEDIUM | MERCK Patent Gesellschaft mit beschränkter Haftung (DE) | 1991-04-04 | — | — | WO | disclosed |