Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLA2G1B | P04054 | 1/20 | 0.36 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.36 |
| ▸ | PRKCQ | Q04759 | 5/20 | 0.36 |
| ▸ | PRKCA | P17252 | 2/20 | 0.36 |
| ▸ | PRKCD | Q05655 | 2/20 | 0.36 |
| ▸ | SCN10A | Q9Y5Y9 | 6/20 | 0.36 |
| ▸ | TYK2 | P29597 | 1/20 | 0.36 |
| ▸ | CAMK1D | Q8IU85 | 1/20 | 0.35 |
| ▸ | AR | P10275 | 1/20 | 0.34 |
| ▸ | CASP1 | P29466 | 1/20 | 0.34 |
| ▸ | CASP5 | P51878 | 1/20 | 0.34 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.34 |
| ▸ | LCK | P06239 | 1/20 | 0.34 |
| ▸ | KDR | P35968 | 1/20 | 0.34 |
| ▸ | TEK | Q02763 | 1/20 | 0.34 |
| ▸ | PLAU | P00749 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8964982 | 0.90 | PRKCA (0.49) | PRKCQPRKCAPRKCD | |
| SCHEMBL8970370 | 0.85 | CASP1 (0.37) | PRKCQPRKCAPRKCDSCN10ATYK2 | |
| SCHEMBL8965113 | 0.81 | PRKCQ (0.55) | PRKCQPRKCAPRKCD | |
| SCHEMBL8969734 | 0.81 | PRKCQ (0.55) | PRKCQPRKCAPRKCD | |
| SCHEMBL11993709 | 0.78 | PRKCQ (0.45) | PRKCQPRKCAPRKCDTYK2AR | |
| SCHEMBL8970201 | 0.78 | PRKCQ (0.53) | PRKCQPRKCAPRKCDSCN10A | |
| SCHEMBL9008503 | 0.77 | PRKCQ (0.47) | PRKCQPRKCAPRKCDCASP1CASP5 | |
| SCHEMBL11993710 | 0.72 | PRKCQ (0.42) | PRKCQPRKCAPRKCDOPRK1PLAU | |
| SCHEMBL8964883 | 0.72 | PRKCA (0.53) | PRKCQPRKCAPRKCD | |
| SCHEMBL9013278 | 0.72 | PRKCQ (0.53) | PRKCQPRKCAPRKCD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8188071-B2 | Amino substituted pyridines as potent kinase inhibitors | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2012-05-29 | — | — | US | disclosed |