Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CASP1 | P29466 | 2/20 | 0.37 |
| ▸ | CASP5 | P51878 | 2/20 | 0.37 |
| ▸ | PRKCQ | Q04759 | 5/20 | 0.37 |
| ▸ | SCN10A | Q9Y5Y9 | 6/20 | 0.35 |
| ▸ | PRKCA | P17252 | 3/20 | 0.35 |
| ▸ | PRKCD | Q05655 | 3/20 | 0.35 |
| ▸ | TYK2 | P29597 | 1/20 | 0.35 |
| ▸ | CASP4 | P49662 | 1/20 | 0.34 |
| ▸ | CAMK1D | Q8IU85 | 2/20 | 0.33 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.33 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.33 |
| ▸ | LCK | P06239 | 1/20 | 0.33 |
| ▸ | KDR | P35968 | 1/20 | 0.33 |
| ▸ | TEK | Q02763 | 1/20 | 0.33 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.33 |
| ▸ | BMPR1A | P36894 | 1/20 | 0.33 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.33 |
| ▸ | ACVRL1 | P37023 | 1/20 | 0.33 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9008503 | 0.91 | PRKCQ (0.47) | CASP1CASP5PRKCQPRKCAPRKCD | |
| SCHEMBL8970382 | 0.85 | PLA2G1B (0.36) | CASP1CASP5PRKCQSCN10APRKCA | |
| SCHEMBL8970017 | 0.82 | PRKCQ (0.55) | PRKCQPRKCAPRKCD | |
| SCHEMBL13857168 | 0.80 | PRKCA (0.39) | CASP1CASP5PRKCQPRKCAPRKCD | |
| SCHEMBL8964982 | 0.76 | PRKCA (0.49) | PRKCQPRKCAPRKCD | |
| SCHEMBL8970201 | 0.76 | PRKCQ (0.53) | PRKCQSCN10APRKCAPRKCD | |
| SCHEMBL1481443 | 0.75 | PRKCQ (0.48) | PRKCQPRKCAPRKCD | |
| SCHEMBL8970152 | 0.74 | PRKCQ (0.69) | PRKCQPRKCAPRKCD | |
| SCHEMBL9011731 | 0.74 | PRKCQ (0.51) | PRKCQPRKCAPRKCDBMPR1BBMPR1A | |
| SCHEMBL8970210 | 0.73 | PRKCQ (0.49) | PRKCQPRKCAPRKCD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8188071-B2 | Amino substituted pyridines as potent kinase inhibitors | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2012-05-29 | — | — | US | disclosed |