Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.53 |
| ▸ | HTR1A | P08908 | 1/20 | 0.53 |
| ▸ | DRD2 | P14416 | 1/20 | 0.53 |
| ▸ | HTR1D | P28221 | 1/20 | 0.49 |
| ▸ | HTR1B | P28222 | 1/20 | 0.49 |
| ▸ | MTNR1A | P48039 | 3/20 | 0.49 |
| ▸ | MTNR1B | P49286 | 3/20 | 0.49 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.49 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.49 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.49 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.49 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.49 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.49 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8970411 | 0.92 | SIGMAR1 (0.58) | SIGMAR1HTR1ADRD2MTNR1AMTNR1B | |
| SCHEMBL3732776 | 0.90 | SIGMAR1 (0.54) | SIGMAR1HTR1ADRD2MTNR1AMTNR1B | |
| SCHEMBL8970307 | 0.83 | MTNR1A (0.62) | SIGMAR1HTR1ADRD2MTNR1AMTNR1B | |
| SCHEMBL8970511 | 0.81 | SIGMAR1 (0.50) | SIGMAR1HTR1ADRD2MTNR1AMTNR1B | |
| SCHEMBL8969631 | 0.80 | MTNR1A (0.51) | SIGMAR1HTR1ADRD2HTR1DHTR1B | |
| SCHEMBL8972304 | 0.79 | MTNR1A (0.49) | DRD2MTNR1AMTNR1BCHRM2CHRM1 | |
| SCHEMBL8970480 | 0.79 | MTNR1A (0.53) | SIGMAR1HTR1ADRD2MTNR1AMTNR1B | |
| SCHEMBL8970649 | 0.77 | BACE1 (0.47) | SIGMAR1HTR1ADRD2MTNR1AMTNR1B | |
| SCHEMBL8969041 | 0.77 | CHRM2 (0.51) | HTR1ADRD2MTNR1AMTNR1BCHRM2 | |
| SCHEMBL9382674 | 0.75 | CHRM2 (0.45) | SIGMAR1HTR1ADRD2HTR1BMTNR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5585392-A | TREATING OR PREVENTING STROKES | BAYER AKTIENGESELLSCHAFT (DE) | 1996-12-17 | — | — | US | disclosed |
| US-5506246-A | Method for treating depression using substituted aminomethyltetralins and their heterocyclic analogues | BAYER AKTIENGESELLSCHAFT (DE) | 1996-04-09 | — | — | US | disclosed |
| EP-0352613-B1 | Substituted amino methyl tetralines, and their heterocyclic analogous compounds | BAYER AG (DE) | 1994-04-20 | — | — | EP | disclosed |
| US-5300523-A | Binding serotonin receptors, treating nervous system disorders | BAYER AKTIENGESELLSCHAFT (DE) | 1994-04-05 | — | — | US | disclosed |
| US-5137901-A | For binding 5-HT 1 receptors; treating central nervous system disorders | BAYER AKTIENGESELLSCHAFT (DE) | 1992-08-11 | — | — | US | disclosed |
| EP-0352613-A2 | Substituted amino methyl tetralines, and their heterocyclic analogous compounds | BAYER AG (DE) | 1990-01-31 | — | — | EP | disclosed |