Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.50 |
| ▸ | HTR1A | P08908 | 1/20 | 0.50 |
| ▸ | MTNR1A | P48039 | 6/20 | 0.48 |
| ▸ | MTNR1B | P49286 | 6/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.47 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.46 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.46 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.46 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.46 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.46 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.46 |
| ▸ | DRD2 | P14416 | 1/20 | 0.44 |
| ▸ | CA1 | P00915 | 1/20 | 0.44 |
| ▸ | CA2 | P00918 | 1/20 | 0.44 |
| ▸ | ACHE | P22303 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8970411 | 0.81 | SIGMAR1 (0.58) | SIGMAR1HTR1AMTNR1AMTNR1BCYP1A2 | |
| SCHEMBL8970407 | 0.81 | SIGMAR1 (0.53) | SIGMAR1HTR1AMTNR1AMTNR1BCHRM2 | |
| SCHEMBL8970307 | 0.73 | MTNR1A (0.62) | SIGMAR1HTR1AMTNR1AMTNR1BCYP1A2 | |
| SCHEMBL3732776 | 0.73 | SIGMAR1 (0.54) | SIGMAR1HTR1AMTNR1AMTNR1BCHRM2 | |
| SCHEMBL8969631 | 0.73 | MTNR1A (0.51) | SIGMAR1HTR1AMTNR1AMTNR1BCYP1A2 | |
| SCHEMBL8970649 | 0.72 | BACE1 (0.47) | SIGMAR1HTR1AMTNR1AMTNR1BCHRM2 | |
| SCHEMBL12635378 | 0.71 | CHRM2 (0.62) | SIGMAR1HTR1AMTNR1AMTNR1BCYP1A2 | |
| SCHEMBL8970480 | 0.71 | MTNR1A (0.53) | SIGMAR1HTR1AMTNR1AMTNR1BCYP1A2 | |
| SCHEMBL12072969 | 0.71 | DRD2 (0.65) | SIGMAR1MTNR1AMTNR1BCHRM2CHRM1 | |
| SCHEMBL8132467 | 0.71 | CHRM2 (0.60) | SIGMAR1HTR1AMTNR1AMTNR1BCYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5585392-A | TREATING OR PREVENTING STROKES | BAYER AKTIENGESELLSCHAFT (DE) | 1996-12-17 | — | — | US | disclosed |
| US-5506246-A | Method for treating depression using substituted aminomethyltetralins and their heterocyclic analogues | BAYER AKTIENGESELLSCHAFT (DE) | 1996-04-09 | — | — | US | disclosed |
| EP-0352613-B1 | Substituted amino methyl tetralines, and their heterocyclic analogous compounds | BAYER AG (DE) | 1994-04-20 | — | — | EP | disclosed |
| US-5300523-A | Binding serotonin receptors, treating nervous system disorders | BAYER AKTIENGESELLSCHAFT (DE) | 1994-04-05 | — | — | US | disclosed |
| US-5137901-A | For binding 5-HT 1 receptors; treating central nervous system disorders | BAYER AKTIENGESELLSCHAFT (DE) | 1992-08-11 | — | — | US | disclosed |
| EP-0352613-A2 | Substituted amino methyl tetralines, and their heterocyclic analogous compounds | BAYER AG (DE) | 1990-01-31 | — | — | EP | disclosed |