Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR1A | P08908 | 10/20 | 0.64 |
| ▸ | HTR1D | P28221 | 10/20 | 0.64 |
| ▸ | POLB | P06746 | 1/20 | 0.59 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.59 |
| ▸ | CA2 | P00918 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27471154 | 0.88 | HTR1A (0.60) | HTR1AHTR1DCA2 | |
| SCHEMBL27478384 | 0.85 | HTR1A (0.64) | HTR1AHTR1DCA2 | |
| SCHEMBL7201735 | 0.85 | HTR1A (0.64) | HTR1AHTR1DCA2 | |
| SCHEMBL8052654 | 0.83 | HTR1A (0.66) | HTR1AHTR1DCA2 | |
| SCHEMBL8864373 | 0.83 | HTR1A (0.66) | HTR1AHTR1DCA2 | |
| SCHEMBL8049371 | 0.82 | HTR1A (0.60) | HTR1AHTR1DCA2 | |
| SCHEMBL8879867 | 0.82 | HTR1A (0.60) | HTR1AHTR1DCA2 | |
| SCHEMBL6921396 | 0.81 | CA2 (0.62) | HTR1AHTR1DCA2 | |
| SCHEMBL27369359 | 0.81 | HTR1A (0.56) | HTR1AHTR1DCA2 | |
| SCHEMBL5723599 | 0.81 | HTR1A (0.67) | HTR1AHTR1DCA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5585392-A | TREATING OR PREVENTING STROKES | BAYER AKTIENGESELLSCHAFT (DE) | 1996-12-17 | — | — | US | disclosed |
| US-5506246-A | Method for treating depression using substituted aminomethyltetralins and their heterocyclic analogues | BAYER AKTIENGESELLSCHAFT (DE) | 1996-04-09 | — | — | US | disclosed |
| EP-0352613-B1 | Substituted amino methyl tetralines, and their heterocyclic analogous compounds | BAYER AG (DE) | 1994-04-20 | — | — | EP | disclosed |
| US-5300523-A | Binding serotonin receptors, treating nervous system disorders | BAYER AKTIENGESELLSCHAFT (DE) | 1994-04-05 | — | — | US | disclosed |
| US-5137901-A | For binding 5-HT 1 receptors; treating central nervous system disorders | BAYER AKTIENGESELLSCHAFT (DE) | 1992-08-11 | — | — | US | disclosed |
| EP-0352613-A2 | Substituted amino methyl tetralines, and their heterocyclic analogous compounds | BAYER AG (DE) | 1990-01-31 | — | — | EP | disclosed |