Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 3/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.36 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 3/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.31 |
| ▸ | PTP4A3 | O75365 | 1/20 | 0.31 |
| ▸ | PTP4A1 | Q93096 | 1/20 | 0.31 |
| ▸ | PKM | P14618 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
| ▸ | SNCA | P37840 | 1/20 | 0.30 |
| ▸ | APP | P05067 | 1/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | GLA | P06280 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9167074 | 0.88 | TSHR (0.36) | CYP3A4MAPTTSHRCACNA1BAPBA1 | |
| SCHEMBL10548645 | 0.85 | TSHR (0.38) | CYP3A4MAPTTSHRCACNA1BAPBA1 | |
| SCHEMBL10924650 | 0.85 | CYP3A4 (0.33) | CYP3A4MAPTTSHRCACNA1BAPBA1 | |
| SCHEMBL10545349 | 0.81 | TDP1 (0.36) | CYP3A4TSHRTDP1 | |
| SCHEMBL9164800 | 0.80 | TSHR (0.31) | TSHR | |
| SCHEMBL10561972 | 0.79 | TSHR (0.30) | TSHR | |
| SCHEMBL177943 | 0.78 | CYP3A4 (0.48) | CYP3A4MAPTTSHRCACNA1BAPBA1 | |
| SCHEMBL2541412 | 0.78 | CYP3A4 (0.35) | CYP3A4MAPTTSHRCACNA1BAPBA1 | |
| SCHEMBL6545801 | 0.78 | CYP3A4 (0.35) | CYP3A4MAPTTSHRCACNA1BAPBA1 | |
| SCHEMBL7512684 | 0.76 | CYP3A4 (0.46) | CYP3A4MAPTTSHRCACNA1BAPBA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5523430-A | Protein farnesyl transferase inhibitors | BRISTOL-MYERS SQUIBB COMPANY (US) | 1996-06-04 | — | — | US | disclosed |