SCHEMBL8970993

SCHEMBL8970993

COC(=O)C(N)(CN)C(=O)OC

nearest known ligand 0.36

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
DGAT1 O75907 1/20 0.36
TSHR P16473 3/20 0.33
KDM4E B2RXH2 2/20 0.33
LMNA P02545 2/20 0.33
KCNN4 O15554 1/20 0.32
ALDH1A1 P00352 1/20 0.32
HSD17B10 Q99714 1/20 0.31
MGAM O43451 1/20 0.31
GAA P10253 1/20 0.31
SI P14410 1/20 0.31
MGAM2 Q2M2H8 1/20 0.31
LOXL2 Q9Y4K0 1/20 0.30
TET2 Q6N021 1/20 0.30
KMT2A Q03164 1/20 0.30
SMN1; SMN2 Q16637 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL7366566 0.88 SMN1; SMN2 (0.33) DGAT1KDM4ELMNAKCNN4SMN1; SMN2
SCHEMBL5498917 0.87 DGAT1 (0.52) DGAT1
SCHEMBL12116983 0.77
SCHEMBL29255120 0.76 KMT2A (0.50) LMNAKCNN4ALDH1A1KMT2ASMN1; SMN2
SCHEMBL18817843 0.75 DGAT1 (0.43) DGAT1KDM4E
Hydrochloric Acid SCHEMBL1315491 0.75 KDM4E (0.38) DGAT1TSHRKDM4ELMNAKCNN4
SCHEMBL29025486 0.75
SCHEMBL291019 0.74
SCHEMBL27858824 0.73 MEN1 (0.38) DGAT1TSHRKCNN4ALDH1A1KMT2A
SCHEMBL1675844 0.72

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0298636-B1 Process for the production of carbamates BP CHEM INT LTD (GB) 1996-03-20 EP disclosed
US-5286265-A Carbamates, their production and use as fuels additives BP CHEMICALS LIMITED (GB) 1994-02-15 US disclosed
US-5126477-A Detergents for internal combustion engine fuels BP CHEMICALS LIMITED (GB) 1992-06-30 US disclosed
US-5103041-A Reacting amine and dihydrocarbyl carbonate in presence of amidine catalyst BP CHEMICALS LIMITED (GB) 1992-04-07 US disclosed
EP-0298636-A1 Process for the production of carbamates BP Chemicals Limited (GB) 1989-01-11 EP disclosed
WO-1988010250-A1 NOVEL CARBAMATES, THEIR PRODUCTION AND USE AS FUELS ADDITIVES BP CHEMICALS LIMITED (GB) 1988-12-29 WO disclosed