Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR3 | P51677 | 3/20 | 0.57 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.55 |
| ▸ | ACHE | P22303 | 1/20 | 0.51 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.50 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.49 |
| ▸ | HTR2A | P28223 | 2/20 | 0.48 |
| ▸ | HTR2C | P28335 | 1/20 | 0.48 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8971088 | 1.00 | CCR3 (0.57) | CCR3ALDH1A1ACHESLC6A3SIGMAR1 | |
| SCHEMBL9427625 | 0.88 | CCR3 (0.56) | CCR3ALDH1A1ACHEHTR2AHTR2C | |
| SCHEMBL9427623 | 0.88 | CCR3 (0.56) | CCR3ALDH1A1ACHEHTR2AHTR2C | |
| SCHEMBL8971012 | 0.84 | ADRA1D (0.61) | CCR3ACHE | |
| SCHEMBL1101922 | 0.81 | ALDH1A1 (0.70) | ALDH1A1 | |
| SCHEMBL9599982 | 0.81 | CCR3 (0.55) | CCR3ACHESLC6A3HTR2AHTR2C | |
| SCHEMBL8971172 | 0.80 | CCR3 (0.49) | CCR3ACHESLC6A3SIGMAR1HTR2A | |
| SCHEMBL8971180 | 0.80 | CCR3 (0.49) | CCR3ACHESLC6A3SIGMAR1HTR2A | |
| SCHEMBL8970124 | 0.77 | CCR3 (0.47) | CCR3ACHESIGMAR1HTR2A | |
| SCHEMBL8970108 | 0.77 | CCR3 (0.47) | CCR3ACHESIGMAR1HTR2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5480892-A | SIGMA RECEPTOR ANTAGONISTS; TREATMENT OF PHYSIOLOGICAL OR DRUG INDUCED PSYCHOSIS AND DYSKINESIA | THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1996-01-02 | — | — | US | disclosed |
| US-5356906-A | (N-phthalimidoalkyl) piperidines useful as treatments for psychosis | THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1994-10-18 | — | — | US | disclosed |
| WO-1993022310-A1 | (N-PHTHALIMIDOALKYL)PIPERIDINES FOR THE TREATMENT OF PSYCHOSES | THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1993-11-11 | — | — | WO | disclosed |
| WO-1991006297-A1 | (N-PHTHALIMIDOALKYL) PIPERIDINES | THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1991-05-16 | — | — | WO | disclosed |