Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | SLC6A4 | P31645 | 3/20 | 0.39 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.39 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.39 |
| ▸ | ALPL | P05186 | 1/20 | 0.39 |
| ▸ | GBA1 | P04062 | 1/20 | 0.37 |
| ▸ | ACE | P12821 | 6/20 | 0.36 |
| ▸ | GABRA1 | P14867 | 3/20 | 0.36 |
| ▸ | GABRG2 | P18507 | 3/20 | 0.36 |
| ▸ | GABRB3 | P28472 | 3/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | CASR | P41180 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9427633 | 0.89 | ALDH1A1 (0.45) | ALDH1A1SLC6A4SLC6A2SLC6A3ALPL | |
| SCHEMBL8971016 | 0.82 | TDP1 (0.41) | ALDH1A1SLC6A4SLC6A2SLC6A3GBA1 | |
| SCHEMBL9428075 | 0.75 | ALDH1A1 (0.41) | ALDH1A1SLC6A4SLC6A2SLC6A3ALPL | |
| SCHEMBL493666 | 0.72 | MC4R (0.48) | SLC6A4SLC6A2SLC6A3GBA1KMT2A | |
| SCHEMBL8969997 | 0.69 | GBA1 (0.47) | SLC6A4SLC6A2SLC6A3GBA1 | |
| SCHEMBL7875085 | 0.69 | GBA1 (0.47) | SLC6A4SLC6A2SLC6A3GBA1KMT2A | |
| SCHEMBL9978780 | 0.69 | GBA1 (0.47) | SLC6A4SLC6A2SLC6A3GBA1 | |
| SCHEMBL9428081 | 0.69 | ACHE (0.45) | ALDH1A1ACE | |
| SCHEMBL27536629 | 0.69 | CPN1 (0.53) | SLC6A4SLC6A2SLC6A3GBA1L3MBTL1 | |
| SCHEMBL1101922 | 0.68 | ALDH1A1 (0.70) | ALDH1A1KMT2AL3MBTL1CASR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5480892-A | SIGMA RECEPTOR ANTAGONISTS; TREATMENT OF PHYSIOLOGICAL OR DRUG INDUCED PSYCHOSIS AND DYSKINESIA | THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1996-01-02 | — | — | US | disclosed |
| US-5356906-A | (N-phthalimidoalkyl) piperidines useful as treatments for psychosis | THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1994-10-18 | — | — | US | disclosed |
| WO-1993022310-A1 | (N-PHTHALIMIDOALKYL)PIPERIDINES FOR THE TREATMENT OF PSYCHOSES | THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1993-11-11 | — | — | WO | disclosed |
| WO-1991006297-A1 | (N-PHTHALIMIDOALKYL) PIPERIDINES | THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1991-05-16 | — | — | WO | disclosed |