Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | F2 | P00734 | 4/20 | 0.42 |
| ▸ | F10 | P00742 | 4/20 | 0.42 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.42 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.42 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.42 |
| ▸ | ST14 | Q9Y5Y6 | 1/20 | 0.42 |
| ▸ | LOX | P28300 | 1/20 | 0.41 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.41 |
| ▸ | HSD17B14 | Q9BPX1 | 1/20 | 0.40 |
| ▸ | LTA4H | P09960 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8972343 | 0.86 | MEN1 (0.49) | TSHRCYP3A4F2F10PRSS1 | |
| SCHEMBL10988883 | 0.84 | MEN1 (0.44) | TSHRCYP3A4F2F10PRSS1 | |
| SCHEMBL10977442 | 0.84 | MEN1 (0.51) | TSHRCYP3A4F2F10PRSS1 | |
| SCHEMBL10978111 | 0.83 | CYP1A2 (0.50) | TSHRCYP3A4F2F10MAP4K4 | |
| SCHEMBL11178628 | 0.82 | MAP4K4 (0.49) | TSHRCYP3A4F2F10ALDH1A1 | |
| SCHEMBL2521152 | 0.82 | LTA4H (0.58) | TSHRF2F10PRSS1PRSS2 | |
| SCHEMBL15871857 | 0.81 | LOXL2 (0.55) | F2F10PRSS1PRSS2PRSS3 | |
| SCHEMBL954527 | 0.81 | LOXL2 (0.48) | TSHRF2F10PRSS1PRSS2 | |
| SCHEMBL7040294 | 0.75 | HTT (0.48) | TSHRF2F10PRSS1PRSS2 | |
| SCHEMBL2144034 | 0.75 | L3MBTL1 (0.54) | TSHRF2F10PRSS1PRSS2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-4499276-A | WITH A BASE AND REDUCING AGENT IN PRESENCE OF PHASE TRANSFER COMPOUND | THE DOW CHEMICAL COMPANY (US) | 1985-02-12 | — | — | US | claimed |
| US-4499277-A | Reduction of trichloromethylpyridines to dichloromethylpyridines | THE DOW CHEMICAL COMPANY (US) | 1985-02-12 | — | — | US | claimed |
| EP-0030101-B1 | PREPARATION OF (DICHLOROMETHYL) PYRIDINES BY REDUCTIVE DECHLORINATION | THE DOW CHEMICAL COMPANY (US) | 1983-06-08 | — | — | EP | claimed |
| EP-0030101-A1 | Preparation of (dichloromethyl) pyridines by reductive dechlorination | THE DOW CHEMICAL COMPANY (US) | 1981-06-10 | — | — | EP | claimed |
| US-4260766-A | Preparation of (dichloromethyl) pyridines by reductive dechlorination | THE DOW CHEMICAL COMPANY (US) | 1981-04-07 | — | — | US | claimed |
| EP-0548855-B1 | Method for producing dichloromethylpyridines | ISHIHARA SANGYO KAISHA (JP) | 1996-03-20 | — | — | EP | disclosed |
| US-5290944-A | Reduction of corresponding trichloromethyl pyridine with dialkyl or trialkyl phosphite | ISHIHARA SANGYO KAISHA LTD. (JP) | 1994-03-01 | — | — | US | disclosed |
| EP-0548855-A1 | Method for producing dichloromethylpyridines | ISHIHARA SANGYO KAISHA, LTD. (JP) | 1993-06-30 | — | — | EP | disclosed |
| US-4499276-A | WITH A BASE AND REDUCING AGENT IN PRESENCE OF PHASE TRANSFER COMPOUND | THE DOW CHEMICAL COMPANY (US) | 1985-02-12 | — | — | US | disclosed |
| US-4499277-A | Reduction of trichloromethylpyridines to dichloromethylpyridines | THE DOW CHEMICAL COMPANY (US) | 1985-02-12 | — | — | US | disclosed |
| EP-0030101-B1 | PREPARATION OF (DICHLOROMETHYL) PYRIDINES BY REDUCTIVE DECHLORINATION | THE DOW CHEMICAL COMPANY (US) | 1983-06-08 | — | — | EP | disclosed |
| EP-0030101-A1 | Preparation of (dichloromethyl) pyridines by reductive dechlorination | THE DOW CHEMICAL COMPANY (US) | 1981-06-10 | — | — | EP | disclosed |
| US-4260766-A | Preparation of (dichloromethyl) pyridines by reductive dechlorination | THE DOW CHEMICAL COMPANY (US) | 1981-04-07 | — | — | US | disclosed |