Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TTBK1 | Q5TCY1 | 5/20 | 0.38 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.38 |
| ▸ | CHUK | O15111 | 7/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | CNR1 | P21554 | 1/20 | 0.34 |
| ▸ | CNR2 | P34972 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.33 |
| ▸ | PLAU | P00749 | 1/20 | 0.33 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.33 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.33 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4521359 | 0.87 | MCHR1 (0.42) | TNIKCHUKCNR1CNR2 | |
| SCHEMBL18034675 | 0.79 | TTBK1 (0.43) | TTBK1CHUKADRA2AADRA2BADRA2C | |
| SCHEMBL4520127 | 0.79 | TTBK1 (0.38) | TTBK1CHUKKMT2AL3MBTL1PLAU | |
| SCHEMBL25486882 | 0.79 | TTBK1 (0.38) | TTBK1CHUKKMT2AL3MBTL1 | |
| SCHEMBL739722 | 0.79 | GRM5 (0.47) | TTBK1TNIKCHUKKMT2A | |
| SCHEMBL16673635 | 0.75 | P4HA1 (0.46) | MAPT | |
| SCHEMBL3511191 | 0.73 | LMNA (0.35) | TTBK1CHUKKMT2AMAPTSMN1; SMN2 | |
| SCHEMBL8973225 | 0.72 | ADRA2A (0.36) | PTK2L3MBTL1PLAUADRA2AADRA2B | |
| SCHEMBL11217017 | 0.71 | MAPT (0.55) | TNIKMEN1KMT2AMAPTSMN1; SMN2 | |
| SCHEMBL1201922 | 0.70 | GRM5 (0.49) | MAPTSMN1; SMN2L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1242426-B1 | GAMMA-HYDROXY-2-(FLUOROALKYLAMINOCARBONYL)-1-PIPERAZINEPENTANAMIDES AS HIV PROTEASE INHIBITORS | MERCK & CO INC (US) | 2007-10-31 | — | — | EP | disclosed |
| US-5534635-A | Process for preparing pyridine-2-carboxamides | HOFFMANN-LA ROCHE INC. (US) | 1996-07-09 | — | — | US | disclosed |
| US-5380861-A | Process for preparing pyridine 2-carboxamides | HOFFMANN-LA ROCHE INC. (US) | 1995-01-10 | — | — | US | disclosed |