Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADRA2A | P08913 | 12/20 | 0.73 |
| ▸ | ADRA2B | P18089 | 12/20 | 0.73 |
| ▸ | ADRA2C | P18825 | 12/20 | 0.73 |
| ▸ | ADRA1D | P25100 | 11/20 | 0.73 |
| ▸ | ADRA1B | P35368 | 9/20 | 0.53 |
| ▸ | ADRA1A | P35348 | 8/20 | 0.53 |
| ▸ | MAPT | P10636 | 3/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.53 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.53 |
| ▸ | HTR1A | P08908 | 1/20 | 0.53 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.53 |
| ▸ | HPGD | P15428 | 1/20 | 0.53 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.53 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.53 |
| ▸ | BLM | P54132 | 1/20 | 0.53 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7031798 | 0.85 | ADRA2A (1.00) | ADRA2AADRA2BADRA2CADRA1DADRA1B | |
| SCHEMBL253111 | 0.79 | ADRA2A (0.82) | ADRA2AADRA2BADRA2CADRA1DADRA1B | |
| SCHEMBL7784448 | 0.74 | ADRA2C (0.70) | ADRA2AADRA2BADRA2CADRA1DADRA1B | |
| SCHEMBL1551650 | 0.74 | SMN1; SMN2 (0.50) | MAPTALDH1A1LMNACYP1A2CYP3A4 | |
| SCHEMBL251823 | 0.73 | ADRA2A (0.75) | ADRA2AADRA2BADRA2CADRA1DADRA1B | |
| SCHEMBL5827504 | 0.72 | HTR1D (0.66) | ADRA2AADRA2BADRA2CADRA1DADRA1B | |
| SCHEMBL7032974 | 0.72 | ADRA2A (0.73) | ADRA2AADRA2BADRA2CADRA1DADRA1B | |
| Brimonidine SCHEMBL29374525 | 0.71 | ADRA2A (1.00) | ADRA2AADRA2BADRA2CADRA1DADRA1B | |
| Brimonidine SCHEMBL20511531 | 0.71 | ADRA2A (1.00) | ADRA2AADRA2BADRA2CADRA1DADRA1B | |
| Brimonidine SCHEMBL24670 | 0.71 | ADRA2A (1.00) | ADRA2AADRA2BADRA2CADRA1DADRA1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5587376-A | ANTIISCHEMIC AGENTS, DECONGESTANTS | ALLERGAN (US) | 1996-12-24 | — | — | US | disclosed |
| EP-0723447-A1 | METHODS FOR USING (2-IMIDAZOLIN-2-YLAMINO) QUINOXALINE DERIVATIVES | Allergan (US) | 1996-07-31 | — | — | EP | disclosed |
| WO-1995010280-A1 | METHODS FOR USING (2-IMIDAZOLIN-2-YLAMINO) QUINOXALINE DERIVATIVES | ALLERGAN (US) | 1995-04-20 | — | — | WO | disclosed |